Female adipose tissue has improved adaptability and metabolic health compared to males in aged obesity02-13-2020
Aging-US Volume 12, Issue 2 reported that Younger females are protected from adipose inflammation, but older post-menopausal females exhibit exaggerated visceral adip...Read More
Pharmacological inhibition of G9a/GLP restores cognition and reduces oxidative stress, neuroinflammation and β-Amyloid plaques in an early-onset Alzheimer’s disease mouse model02-13-2020 Read More
The deep age predictors can help advance aging research by establishing ca...Read More
Subunit contribution to NMDA receptor hypofunction and redox sensitivity of hippocampal synaptic transmission during aging10-06-2019
The researchers examined the contribution of N-methyl-D-aspartate receptor subunits in the redox-mediated decline in NMDAR function during aging.
Glu N2A and Glu N2B selective antagonists decreased peak NMDAR c...Read More
Conclusions from a behavioral aging study on male and female F2 hybrid mice on age-related behavior, buoyancy in water-based tests, and an ethical method to assess lifespan10-05-2019
Due to strain-specific behavioral idiosyncrasies, inbred mouse strains are suboptimal research models for behavioral aging studies.
The researchers found that both males and females demonstrated decreased explo...Read More
The researchers recruited healthy older participants to two groups according to their history of tea drinking frequency and investigated both functional and structural networks to reveal the role of tea drinking on br...Read More
In adult skeletal muscle, loss of myofiber integrity caused by mechanical injuries or diseases are repaired by resident muscle stem cells, called satellite cells, which promptly exit from quiescence after disruption o...Read More
The effects of dietary fatty acids on bone, hematopoietic marrow and marrow adipose tissue in a murine model of senile osteoporosis10-02-2019
Marrow adipose tissue expansion and associated lipotoxicity are important drivers of age-related bone loss and hematopoietic bone marrow atrophy.
Dr. Gustavo Duque from the Australian Institute for Musculoskele...Read More
For Aging’s Volume 11, Issue 18, the Journal devoted the Cover to a research paper by Dr. Alejandro Martin-Montalvo from the Department of Regeneration and Cell Therapy, Andalusian Ce...Read More
Leukocyte DNAm TL is applicable across the entire age spectrum and is more strongly associated with age than measured leukocyte TL.
Leukocyte DNAm TL outperforms LTL in predicting: i)time-to-death, ii)time-to-c...Read More
In this study, the research team conducted a large-scale epigenome-wide association study of LTL using seven large cohorts the Framingham Heart Study, the Jackson Heart Study, the Womens Health Initiative, the Bogalus...Read More
Rapamycin retards epigenetic ageing of keratinocytes independently of its effects on replicative senescence, proliferation and differentiation06-04-2019
Cessation, or even retardation of the ageing process is an appealing notion that has captured the imagination of humans for millennia. Even if it were possible to rejuvenate our bodies or retard the ageing process, ho...Read More
Exploiting mitochondrial targeting signal(s), TPP and bis‐TPP, for eradicating cancer stem cells (CSCs)06-01-2018
TPP-related compounds may provide a novel chemical strategy for effectively targeting bulk cancer cells and CSCs, while minimizing off-target side-effects in normal cells.
Several independent lines of eviden...Read More
Small extracellular vesicles and their miRNA cargo are anti-apoptotic members of the senescence-associated secretory phenotype06-01-2018
The specific molecular mechanism of selective release and retention of senescence-associated sEV-mi RNAs and the EV-SASP cross talk between different cell types and its consequences in the context of aging and age-ass...Read More
The Grim Reaper arrives for each of us eventually—wouldn’t it be nice to know when? Now UCLA researchers have developed a new tool to help you plan ahead for your date with the Angel of Death.
Named after ...Read More
The researchers found a small core set of genes involved in stemness, proliferation and migration that showed consistent changes with advanced age in cells of renin lineage (CoRL)within the kidney.