Research Paper Volume 12, Issue 9 pp 8506—8522
White matter hyperintensities associated with progression of cerebral small vessel disease: a 7-year Chinese urban community study
- 1 Department of Neurology, National Clinical Research Centre for Aging and Medicine, Huashan Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China
- 2 Institute of Neurology, National Clinical Research Centre for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China
- 3 Centers for Biomedical Engineering, University of Science and Technology of China, Hefei, Anhui, China
- 4 Department of Neurology, Jing’an District Center Hospital, Shanghai, China
- 5 Department of Radiology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China
- 6 Department of Radiology, Jing’an District Center Hospital, Shanghai, China
- 7 Shanghai Health Development Research Center (Shanghai Medical Information Center), Shanghai, China
Received: November 8, 2019 Accepted: April 16, 2020 Published: May 10, 2020https://doi.org/10.18632/aging.103154
How to Cite
Copyright © 2020 Xia et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
We aimed to explore the role of white matter hyperintensities (WMH) in progression of cerebral small vessel disease (CSVD) in an urban community in China over a period of 7 years, and to investigate associations between WMH volume (baseline and progression) and cognitive impairment. CSVD markers and neuropsychological tests at baseline and follow-up of 191 participants of the Shanghai Aging Study (SAS) were assessed. WMH volume were assessed by automatic segmentation based on U-net model. Lacunes, cerebral microbleeds (CMBs) and enlarged perivascular spaces (ePVS) were rated manually. Small vessel disease (SVD) score was rated as the total burden of CSVD markers. Global cognitive function and 5 main cognitive domains (memory, language, spatial construction, attention and executive function) were evaluated by neuropsychological tests. We performed multivariable linear regression and binominal logistic regression. Participants with higher baseline WMH volume developed more progression of WMH volume, increased risk of incident lacunes, incident CMBs, and ePVS progression. WMH (baseline and progression) were associated with decline of executive function. WMH were associated with progression of cerebral small vessel disease and decline of executive function in a Chinese urban community study over a period of 7 years.