Research Paper Volume 12, Issue 9 pp 8702—8709
A novel method for calculating mean erythrocyte age using erythrocyte creatine
- 1 Department of Diagnostic Radiology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan
- 2 Department of Internal Medicine, Hakuhokai Central Hospital, Hyogo, Japan
- 3 Department of Biomedical Laboratory Sciences, Faculty of Health Sciences, Kumamoto University, Kumamoto, Japan
Received: February 23, 2020 Accepted: April 20, 2020 Published: May 11, 2020https://doi.org/10.18632/aging.103193
How to Cite
Copyright © 2020 Kameyama et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Estimating the lifespan of erythrocytes is useful for the differential diagnosis of anemia. However, measuring the lifespan of erythrocytes was very difficult; therefore, it was seldom measured. Erythrocyte creatine (EC) decreases reflecting erythrocyte age. We developed a method to obtain mean erythrocyte age (MRBC) from EC.
We reanalyzed the previously published data from 21 patients with hemolytic anemia, which included EC and the half-life of 51Cr.
MRBC and loge EC showed excellent significant linearity (r = −0.9475, p < 0.001), proving that it could be treated as a mono-exponential relationship within the studied range (EC: 1.45 – 11.76 μmol/g Hb). We established an equation to obtain MRBC (days) from EC (μmol/g Hb): MRBC = −22.84loge EC + 65.83.
This equation allowed calculation of MRBC based on EC which has practical applications such as the diagnosis of anemia.