Research Paper Volume 13, Issue 12 pp 16404—16424

Diagnostic accuracy of high b-value diffusion weighted imaging for patients with prostate cancer: a diagnostic comprehensive analysis

Chao Li1, , Na Li1, , Zhanzhan Li1, , Liangfang Shen1, ,

  • 1 Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan Province 410008, China

Received: April 8, 2021       Accepted: May 31, 2021       Published: June 22, 2021
How to Cite

Copyright: © 2021 Li et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


We performed a meta-analysis to assess the diagnostic accuracy of high b-value diffusion-weighted imaging for patients with prostate cancer. A comprehensive literature search of the PubMed, Excerpta Medica Database, Cochrane Library, China National Knowledge Infrastructure, China Biology Medicine disc, and Wanfang databases from January 1, 1995, to April 30, 2021, was conducted. The quality of the retrieved papers was assessed using the Quality Assessment of Diagnostic Accuracy Studies 2. The sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio, and their 95% confidence intervals (CIs) were evaluated using bivariate mixed effects models. A total of twenty-four articles matched the selection criteria and were finally included after screening the titles, abstracts, and full texts of 641 initial articles. The pooled sensitivity and specificity (95% CI) were 0.84 (0.80–0.87) and 0.87 (0.81–0.91), respectively. The pooled positive and negative likelihood ratios (95% CI) were 6.4 (4.4–9.3) and 0.19 (0.16–0.23), respectively. The diagnostic odds ratio was 34 (95% CI: 22–51). The area under the summary receiver operator characteristic curve was 0.91 (95% CI: 0.88–0.93). Subgroup analysis presents similar results. The diagnostic accuracy of high b-value diffusion-weighted imaging was similarly high in the qualitative and quantitative evaluation of prostate cancer.


EMBASE: Excerpta Medica Database; PLR: positive likelihood ratio; NLR: negative likelihood ratio; DOR: diagnostic odds ratio; AUC: area under the curve; TP: true positive; FP: false positive; FN: false negative; TN: true negative; PSA: prostate-specific antigen; MRI: magnetic resonance imaging; DWI: diffusion-weighted imaging; TRUS: transrectal ultrasound; TSB: tissue sample biopsy; RP: radical prostatectomy; ADC: apparent dispersion coefficient.