Research Paper Volume 13, Issue 23 pp 25213—25240
hsa_circ_0072389, hsa_circ_0072386, hsa_circ_0008621, hsa_circ_0072387, and hsa_circ_0072391 aggravate glioma via miR-338-5p/IKBIP
- 1 The Second Clinical Medical College of Jinan University, Shenzhen People′s Hospital, Shenzhen, China
- 2 Department of Hematology, The Second Clinical Medical College of Jinan University, Shenzhen People′s Hospital, Shenzhen, China
- 3 School of Medicine, Southern University of Science and Technology, Shenzhen, China
Received: February 24, 2021 Accepted: November 11, 2021 Published: December 12, 2021https://doi.org/10.18632/aging.203740
How to Cite
Copyright: © 2021 Liang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Glioma is a primary intracranial tumor with high morbidity and mortality. We acquired miR-338-5p, which suppresses the development of glioma, from the GEO and CGGA databases. In addition, we predicted that hsa_circ_0072389, hsa_circ_0072386, hsa_circ_0008621, hsa_circ_0072387, and hsa_circ_0072391 could relieve the silencing of IKBIP by miR-338-5p. By analyzing genes related to IKBIP expression, possible pathways affecting glioma were identified. This study provides new ideas for investigating multiple circRNAs in ceRNAs.