Research Article Volume 8, Issue 9 pp 1952—1978
PPARβ/δ selectively regulates phenotypic features of age-related macular degeneration
Figure 9. Summary model of selective regulation of dry and wet AMD related pathogenic pathways by PPARβ/δ in AMD vulnerable cells. Ligand activation of PPARβ/δ inhibits lipid accumulation by RPE cells and may have therapeutic effect in dry-AMD. In contrast, antagonism of PPARβ/δ inhibits neovascularization possibly by regulating inflammation and fibrosis in outer-retina.