Nickel chloride (NiCl2) in hepatic toxicity: apoptosis, G2/M cell cycle arrest and inflammatory response

Hongrui Guo; Hengmin Cui; Jing Fang; Zhicai Zuo; Junliang Deng; Xun Wang; Ling Zhao; Kejie Chen; Jie Deng

doi:doi:10.18632/aging.101108

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Research Paper Volume 8, Issue 11 pp 3009—3027

Nickel chloride (NiCl2) in hepatic toxicity: apoptosis, G2/M cell cycle arrest and inflammatory response

Figure 3. NiCl₂ induces apoptosis in the liver. (A) Representative TUNEL and flow cytometric diagram of apoptosis analysis. (B) Changes of the TUNEL positive cells in the liver. (C) Changes of the percentages of annexin V positive cells in the liver. Data are presented with the mean ± standard deviation B:(n=5×5), C: (n=5). *P<0.05, compared with the control group. **P<0.01, compared with the control group.