Research Paper Volume 10, Issue 11 pp 3353—3370

LOC134466 methylation promotes oncogenesis of endometrial carcinoma through LOC134466/hsa-miR-196a-5p/TAC1 axis

Figure 5. Neuroactive ligand-receptor interaction was remarkably up-regulated. (A) Genes involving neuroactive ligand-receptor interaction, for example TACR3, were generally upregulated. (B) Neuroactive ligand-receptor interaction enriched by KEGG was up-regulated. (C) Joyplot of GSEA showed that neuroactive ligand-receptor interaction was upregulated in EC. (D) Dotplot of GSEA which displayed the activation and inactivation of top 16 significantly enriched signaling pathways showed that neuroactive ligand-receptor interaction was activated in EC.