Research Paper Volume 11, Issue 6 pp 1716—1732

Elevated FPR confers to radiochemoresistance and predicts clinical efficacy and outcome of metastatic colorectal cancer patients

Figure 3. Relationship between FPR, clinical characteristics and primary tumor sidedness as well as clinical therapeutic efficacy in present study. (a) progression status in discovery cohort stratified by FPR ; (b) death status in discovery cohort stratified by FPR; (c) overall survival difference between left- and right-sided CRC cases stratified by FPR in discovery cohort; (d) overall survival difference between left- and right-sided CRC cases stratified by FPR in validation cohort; (e) overall survival difference between high- and low-FPR patients in radiochemotherapy subgroup (no palliative resection); (f) overall survival difference between high- and low-FPR patients in palliative resection subgroup. Abbreviation within in Panels 3c-d: A: left-sided patients with low-FPR; B: left-sided mCRC patients with high-FPR; C: right-sided patients with low-FPR; D: right-sided mCRC patients with high-FPR. Abbreviation within in Panels 3e-f: A: low-FPR mCRC patients without radiochemotherapy; B: low-FPR mCRC patient with radiochemotherapy; C: high-FPR mCRC patient without radiochemotherapy; D: high-FPR mCRC patient with radiochemotherapy.