Research Paper Volume 11, Issue 6 pp 1716—1732

Elevated FPR confers to radiochemoresistance and predicts clinical efficacy and outcome of metastatic colorectal cancer patients

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Figure 3. Relationship between FPR, clinical characteristics and primary tumor sidedness as well as clinical therapeutic efficacy in present study. (a) progression status in discovery cohort stratified by FPR ; (b) death status in discovery cohort stratified by FPR; (c) overall survival difference between left- and right-sided CRC cases stratified by FPR in discovery cohort; (d) overall survival difference between left- and right-sided CRC cases stratified by FPR in validation cohort; (e) overall survival difference between high- and low-FPR patients in radiochemotherapy subgroup (no palliative resection); (f) overall survival difference between high- and low-FPR patients in palliative resection subgroup. Abbreviation within in Panels 3c-d: A: left-sided patients with low-FPR; B: left-sided mCRC patients with high-FPR; C: right-sided patients with low-FPR; D: right-sided mCRC patients with high-FPR. Abbreviation within in Panels 3e-f: A: low-FPR mCRC patients without radiochemotherapy; B: low-FPR mCRC patient with radiochemotherapy; C: high-FPR mCRC patient without radiochemotherapy; D: high-FPR mCRC patient with radiochemotherapy.