Research Paper Volume 11, Issue 6 pp 1791—1803

Muscle-derived miR-34a increases with age in circulating extracellular vesicles and induces senescence of bone marrow stem cells

Figure 1. miR-34a is increased in mouse skeletal muscle and in serum EVs with age. (A) Expression levels of miR-34a, miR-155, miR-183, and miR-141 in skeletal muscle of young and aged male and female mice. (B) Expression levels of miR-34a, miR-155, miR-183, and miR-141 in serum EVs from young and aged male and female mice. *P<.05, **P<.01, ***P<.001.