Research Paper Volume 11, Issue 14 pp 5232—5245

Aberrant DNA methylation of synaptophysin is involved in adrenal cortisol-producing adenoma

Figure 5. The mechanism diagram about miR-27a-5p-TET3-SYP signal pathway in adrenocortical adenomas causing CPA. miR-27a-5p suppresses SYP through epigenetic repression by targeting TET3 in adrenocortical adenomas causing CPA. miR-27a-5p-TET3-SYP signalling pathway may play a key role in CPA progression, H295R cell proliferation and cortisol secretion.