Nickel induces inflammatory activation via NF-κB, MAPKs, IRF3 and NLRP3 inflammasome signaling pathways in macrophages

Hongrui Guo; Huan Liu; Zhijie Jian; Hengmin Cui; Jing Fang; Zhicai Zuo; Junliang Deng; Yinglun Li; Xun Wang; Ling Zhao; Yi Geng; Ping Ouyang; Weiming Lai; Zhengli Chen; Chao Huang

doi:doi:10.18632/aging.102570

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Research Paper Volume 11, Issue 23 pp 11659—11672

Nickel induces inflammatory activation via NF-κB, MAPKs, IRF3 and NLRP3 inflammasome signaling pathways in macrophages

Figure 4. NiCl₂ induces pro-inflammatory cytokine production in BMDMs. (A) The mRNA expression levels of inflammatory cytokines after NiCl₂ (0, 0.1, 0.5 and 1.0 mM) treatment for 24h. (B) Inflammatory cytokine expression is quantified in BMDMs cultural medium by ELISA after NiCl₂ (0, 0.1, 0.5 and 1.0 mM) treatment for 24h. Data are presented with the means ± standard deviation (n=5). *p < 0.05 and **p < 0.01, compared with the control group.