Research Paper Volume 12, Issue 1 pp 611—627

Aspirin enhances the sensitivity of colon cancer cells to cisplatin by abrogating the binding of NF-κB to the COX-2 promoter

Figure 1. Aspirin synergizes the inhibiting effect of Cisplatin on cell viability in colon cancer cells. (A) Human colon cancer cells SW620, LoVo, RKO and DLD-1 were treated with different concentrations of Aspirin for 48 h, and the cell viability was tested by MTT assay (n=6). (B) Human colon cancer cells were treated with indicated dose of Cisplatin alone or Cisplatin combined with 2 mM Aspirin for 48 h, and the cell viability was tested by MTT assay (n=6). (C) IC50 values of Cisplatin were calculated by software CVXPT32 in colon cancer cells upon treatment with Cisplatin alone or Cisplatin combined with 2 mM Aspirin. Data were presented as means ± SD, *P<0.05, **P<0.01, ***P<0.001.