Research Paper Volume 12, Issue 3 pp 2123—2131

Bone morphogenetic protein 9, and its genetic variants contribute to susceptibility of idiopathic pulmonary arterial hypertension

Figure 5. BMP9 rs3740297 affect l expression level of MIR-149 and the BMP9 gene in PASMC cells. (A) relative expression level of MIR-149 were measured in PASMC cells. (B) relative expression level of the BMP9 gene were measured in PASMC cells transfected with C allele, or T allele. Cells in different groups were treated with blank control, miR-149 mimic or antagomir-miR-149. Three replicates for each group and the experiment were repeated three times.