Research Paper Volume 12, Issue 3 pp 2595—2609

Notch1/2/3/4 are prognostic biomarker and correlated with immune infiltrates in gastric cancer

Figure 5. Correlation of Notch expression with immune infiltration level in GC. (A) Notch1 expression had significant positive correlations with infiltrating levels of CD4+ T cells (n = 415). (B) Notch2 expression had significant correlations with infiltrating levels of CD4+ T cells, macrophages, neutrophils, and dendritic cells in GC (n = 415). (C) Notch3 expression was significantly related to infiltrating levels of CD4+ T cells and macrophages in GC but no significant correlation with infiltrating level of B cells (n = 415). (D) Notch4 expression had significant positive correlations with infiltrating levels of CD4+ T cells and macrophages in GC (n = 415). Spearman’s correlation was used to analyze correlation between Notch receptors and immune cells.