Research Paper Volume 12, Issue 13 pp 12799—12811

Tomatidine suppresses inflammation in primary articular chondrocytes and attenuates cartilage degradation in osteoarthritic rats

Figure 2. Tomatidine-target genes associated with the top two KEGG pathways. (A) The tomatidine-target genes that are part of the MAPK signaling pathway, including MAPK1 and MAPK3 are associated with proliferation, differentiation, cell survival or anti-apoptotic, and inflammation. (B) Tomatidine-target genes that are part of the Neurotrophin signaling pathway, including MAPK1 and MAPK3 are associated with cellular differentiation, cell survival, and retrograde transport.