Figure 1. Low DAPK1 expression correlates with tumor progression and metastasis in ccRCC patients. (A) DAPK1 mRNA expression in ccRCC (n=531) and adjacent normal kidney tissues (n=72) from the The Cancer Genome Atlas-Kidney Renal clear cell Carcinoma (TCGA-KIRC) database. (B) DAPK1 mRNA expression in paired ccRCC and para-cancerous kidney tissues (n=72) from the TCGA-KIRC database. (C) DAPK1 mRNA expression in primary (n=50) and metastatic ccRCC (n=20) tumors from the GSE43477 dataset. (D) DAPK1 mRNA expression in paired primary and metastatic ccRCC tumors (n=20) from the GSE43477 database. (E–I) Correlation between DAPK1 mRNA expression and clinicopathological parameters, including (E) T stage (T1-T4), (F) pathologic stage (I-IV), (G) tumor grade (G1-G4), (H) distant metastases, and (I) gender (male or female). Note: The data are shown as means ± SEM; ***p<0.001, **p<0.01, *p<0.05.