Figure 3. Univariate associations between longitudinal rates of change in leukocyte telomere length (LTL) and whole blood mitochondrial DNA (WB mtDNA) content. (A) Data show an inverse relationship between ΔLTL/year and WB ΔmtDNA content/year. Shaded area represents the 95% prediction interval. Coefficient of determination (R2) and Pearson's P-value shown. (B) Participants were categorized based on a small (<0.1) or large (>0.1) loss or gain of ΔLTL/year and further stratified according to a small (<10) or large (>10) loss or gain of WB ΔmtDNA content/year. These data show that participants who lost LTL fastest were more likely to preserve or gain WB mtDNA content. (C) Similarly, participants were categorized based on WB ΔmtDNA content/year and stratified according to ΔLTL/year. The data show that participants who lost WB mtDNA fastest were more likely to preserve LTL and vice versa.