Research Paper Volume 12, Issue 15 pp 15196—15221

Inverse relationship between leukocyte telomere length attrition and blood mitochondrial DNA content loss over time

Figure 3. Univariate associations between longitudinal rates of change in leukocyte telomere length (LTL) and whole blood mitochondrial DNA (WB mtDNA) content. (A) Data show an inverse relationship between ΔLTL/year and WB ΔmtDNA content/year. Shaded area represents the 95% prediction interval. Coefficient of determination (R2) and Pearson's P-value shown. (B) Participants were categorized based on a small (<0.1) or large (>0.1) loss or gain of ΔLTL/year and further stratified according to a small (<10) or large (>10) loss or gain of WB ΔmtDNA content/year. These data show that participants who lost LTL fastest were more likely to preserve or gain WB mtDNA content. (C) Similarly, participants were categorized based on WB ΔmtDNA content/year and stratified according to ΔLTL/year. The data show that participants who lost WB mtDNA fastest were more likely to preserve LTL and vice versa.