Increased expression of myelin-associated genes in frontal cortex of <i>SNCA</i> overexpressing rats and Parkinson’s disease patients

Thomas Hentrich; Zinah Wassouf; Christine Ehrhardt; Eva Haas; James D. Mills; Eleonora Aronica; Tiago Fleming Outeiro; Jeannette Hübener-Schmid; Olaf Riess; Nicolas Casadei; Julia M. Schulze-Hentrich

doi:doi:10.18632/aging.103935

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Research Paper Volume 12, Issue 19 pp 18889—18906

Increased expression of myelin-associated genes in frontal cortex of SNCA overexpressing rats and Parkinson’s disease patients

Gene expression patterns point to interactions between SNCA overexpression and age-related adaptations in gene activity. (A) Venn diagram comparing DEGs identified in 5- and 12-month-old TG rats. (B) Hierarchically clustered expression changes (relative to WT_5m) for all 934 DEGs identified in 5- and 12-month-old TG rats partitioned into four main perturbance patterns. (C) Gene clusters (see B) summarized as expression medoids (±SD). Cluster cardinalities indicated in brackets.