Research Paper Volume 12, Issue 19 pp 18928—18941
CD8+ T cells are present at low levels in the white matter with physiological and pathological aging
Comparison of CD3+, CD4+ and CD8+ cells with pathological aging in white matter. Representative images and quantification of CD3 (A–C), CD4 (D–F) and CD8 (G–I) expression in aged individuals and patients with neurodegenerative disease. Data are presented as number of positive cells per mm2 with median bar. Red scale bar: 50 μm; black scale bar: 100 μm. White matter (WM), perivascular region (pv), brain parenchyma (pa).