Research Paper Advance Articles pp 23525—23547

Mutation in histone deacetylase HDA-3 leads to shortened locomotor healthspan in Caenorhabditis elegans

Figure 5. Gene expression is dysregulated in hda-3 mutant. (A) (Left) Volcano plot of differential expression of transcripts from OF1263 hda-3(ix241);dys-1(ix259) (4x BC) vs. WT worms. (Right) Volcano plot of differential expression of transcripts from OF1263 hda-3(ix241);dys-1(ix259) (4x BC) vs. OF1350 dys-1(ix259) (5x BC) worms. Blue points indicate downregulated genes and red points indicate upregulated genes with q value < 0.05 (FDR-adjusted p value). (B) (Left) Venn diagram of number of significantly upregulated transcripts with q < 0.05 in OF1263 vs. WT worms and OF1263 vs. OF1350 worms. (Right) Venn diagram of number of significantly upregulated and downregulated transcripts with P < 0.0001 in OF1263 vs. WT and OF1263 vs. OF1350 worms. Names of commonly upregulated or downregulated genes are indicated within the Venn diagram.