Research Paper Volume 13, Issue 2 pp 2912—2940

Systems pharmacology dissection of Epimedium targeting tumor microenvironment to enhance cytotoxic T lymphocyte responses in lung cancer

The NSCLC-pathway. Distribution of protein targets of Epimedium on the compressed ‘NSCLC-pathway’. Three pathways (VEGF, TNF, PI3K-AKT Signaling Pathway) form the compressed NSCLC pathway. Yellow rectangle remark targets on the NSCLC pathway, blue rectangle represent targets of active compounds and dark blue rectangle represent therapeutic modules. Solid arrows indicate activation, T-arrows indicate inhibition and dotted arrows indicate indirect effect.

Figure 5. The NSCLC-pathway. Distribution of protein targets of Epimedium on the compressed ‘NSCLC-pathway’. Three pathways (VEGF, TNF, PI3K-AKT Signaling Pathway) form the compressed NSCLC pathway. Yellow rectangle remark targets on the NSCLC pathway, blue rectangle represent targets of active compounds and dark blue rectangle represent therapeutic modules. Solid arrows indicate activation, T-arrows indicate inhibition and dotted arrows indicate indirect effect.