Review Volume 13, Issue 12 pp 16859—16872

Molecular switch in human diseases-disintegrin and metalloproteinases, ADAM17

Mechanism of ADAM17-mediated reduced antitumor activity of immune cells. Abbreviations: CEACAM1, carcinoembryonic antigen-related cell adhesion molecule 1; HMGB1, high mobility group protein B1; IRFs, interferon regulatory factors; sTIM3, soluble TIM3; sPD-L1, soluble PD-L1.

Figure 2. Mechanism of ADAM17-mediated reduced antitumor activity of immune cells. Abbreviations: CEACAM1, carcinoembryonic antigen-related cell adhesion molecule 1; HMGB1, high mobility group protein B1; IRFs, interferon regulatory factors; sTIM3, soluble TIM3; sPD-L1, soluble PD-L1.