Research Paper Volume 13, Issue 14 pp 18423—18441

Yiqi Jiemin decoction alleviates allergic rhinitis in a guinea pig model by suppressing inflammation, restoring Th1/Th2 balance, and improving cellular metabolism

YJD treatment alleviates nasal symptoms in AR model guinea pigs. (A) The histogram plots show AR symptom scores for the control, AR model, AR model plus YJD, and AR model plus dexamethasone groups of guinea pigs. The data are represented as means ± SD from 3 independent experiments. *P B) Wright’s-Giemsa staining results show histological changes in nasal mucosal samples from the control, AR model, AR model plus YJD, and AR model plus dexamethasone groups. (C) The histogram plots show the percentage of eosinophils in the Wright’s-Giemsa-stained samples of nasal mucosal samples from the control, AR model, AR model plus YJD, and AR model plus dexamethasone groups. The data was independently analyzed by 3 pathologists based on five different views under a light microscope. *P D) Representative H&E-stained images of nasal mucosal samples from the control, AR model, AR model plus YJD, and AR model plus dexamethasone groups.

Figure 1. YJD treatment alleviates nasal symptoms in AR model guinea pigs. (A) The histogram plots show AR symptom scores for the control, AR model, AR model plus YJD, and AR model plus dexamethasone groups of guinea pigs. The data are represented as means ± SD from 3 independent experiments. *P < 0.05; **P < 0.01; two-way ANOVA. (B) Wright’s-Giemsa staining results show histological changes in nasal mucosal samples from the control, AR model, AR model plus YJD, and AR model plus dexamethasone groups. (C) The histogram plots show the percentage of eosinophils in the Wright’s-Giemsa-stained samples of nasal mucosal samples from the control, AR model, AR model plus YJD, and AR model plus dexamethasone groups. The data was independently analyzed by 3 pathologists based on five different views under a light microscope. *P < 0.05; **P < 0.01; one-way ANOVA. (D) Representative H&E-stained images of nasal mucosal samples from the control, AR model, AR model plus YJD, and AR model plus dexamethasone groups.