Research Paper Volume 13, Issue 14 pp 18423—18441

Yiqi Jiemin decoction alleviates allergic rhinitis in a guinea pig model by suppressing inflammation, restoring Th1/Th2 balance, and improving cellular metabolism

YJD reduces serum levels of pro-inflammatory factors in the AR model guinea pigs and restores the balance of Th1/Th2 immune responses. ELISA assay results show the serum levels of NP-γ (A), ACH (B), NADR (C), IgE (D), HA (E), IFN-γ (F) and IL-4 (G) in the control, AR model, AR model plus YJD, and AR model plus dexamethasone groups. (H) The histogram plots show the IFN-γ/IL-4 ratio based on the serum levels of IFN-γ and IL-4 in the control, AR model, AR model plus YJD, and AR model plus dexamethasone groups. (I) Flow cytometry was used to detect the CD3+IFN-γ + (Th1) cell percentage and CD3+IL-4+ (Th2) cell percentage respectively. *P

Figure 3. YJD reduces serum levels of pro-inflammatory factors in the AR model guinea pigs and restores the balance of Th1/Th2 immune responses. ELISA assay results show the serum levels of NP-γ (A), ACH (B), NADR (C), IgE (D), HA (E), IFN-γ (F) and IL-4 (G) in the control, AR model, AR model plus YJD, and AR model plus dexamethasone groups. (H) The histogram plots show the IFN-γ/IL-4 ratio based on the serum levels of IFN-γ and IL-4 in the control, AR model, AR model plus YJD, and AR model plus dexamethasone groups. (I) Flow cytometry was used to detect the CD3+IFN-γ + (Th1) cell percentage and CD3+IL-4+ (Th2) cell percentage respectively. *P < 0.05; **P < 0.01; one-way ANOVA.