Research Paper Volume 13, Issue 14 pp 18423—18441

Yiqi Jiemin decoction alleviates allergic rhinitis in a guinea pig model by suppressing inflammation, restoring Th1/Th2 balance, and improving cellular metabolism

YJD treatment reverses serum metabolite changes in the AR model guinea pigs. (A–D) Heat map shows clustering of various metabolites as analyzed by LC-HRMS in the control vs. AR model, AR model plus YJD vs. control, AR model vs. AR model plus dexamethasone, and AR model vs. AR model plus YJD groups. (E) Venn diagram shows the common metabolites that are differentially expressed when comparing control vs. AR model, AR model plus YJD vs. control, AR model vs. AR model plus dexamethasone, and AR model vs. AR model plus YJD groups. (F) ELISA assay results show the levels of LPA and GCA metabolites in the serum of control, AR model, AR model plus YJD, and AR model plus dexamethasone groups.

Figure 4. YJD treatment reverses serum metabolite changes in the AR model guinea pigs. (AD) Heat map shows clustering of various metabolites as analyzed by LC-HRMS in the control vs. AR model, AR model plus YJD vs. control, AR model vs. AR model plus dexamethasone, and AR model vs. AR model plus YJD groups. (E) Venn diagram shows the common metabolites that are differentially expressed when comparing control vs. AR model, AR model plus YJD vs. control, AR model vs. AR model plus dexamethasone, and AR model vs. AR model plus YJD groups. (F) ELISA assay results show the levels of LPA and GCA metabolites in the serum of control, AR model, AR model plus YJD, and AR model plus dexamethasone groups.