Research Paper Volume 13, Issue 14 pp 18757—18768

Curcumin in combination with homoharringtonine suppresses lymphoma cell growth by inhibiting the TGF-β/Smad3 signaling pathway

Combination of curcumin with HHT synergistically inhibited lymphoma cell proliferation. (A) U937 or (B) Raji cells were treated with 0, 5, 10, 20, 40, or 80 μM curcumin for 72 h. CCK-8 assay was used to measure cell viability. (C) U937 or (D) Raji cells were treated with 0, 5, 10, 20, 40, 80, or 160 ng/mL HHT for 72 h. CCK-8 assay was used to measure cell viability. (E) U937 or (F) Raji cells were treated with 5 ng/mL HHT plus curcumin (0, 5, 10, 20, or 40 μM) for 72 h. CCK-8 assay was used to measure cell viability. *P **P

Figure 1. Combination of curcumin with HHT synergistically inhibited lymphoma cell proliferation. (A) U937 or (B) Raji cells were treated with 0, 5, 10, 20, 40, or 80 μM curcumin for 72 h. CCK-8 assay was used to measure cell viability. (C) U937 or (D) Raji cells were treated with 0, 5, 10, 20, 40, 80, or 160 ng/mL HHT for 72 h. CCK-8 assay was used to measure cell viability. (E) U937 or (F) Raji cells were treated with 5 ng/mL HHT plus curcumin (0, 5, 10, 20, or 40 μM) for 72 h. CCK-8 assay was used to measure cell viability. *P < 0.05, **P < 0.01 compared to control group.