Research Paper Volume 13, Issue 14 pp 18757—18768

Curcumin in combination with homoharringtonine suppresses lymphoma cell growth by inhibiting the TGF-β/Smad3 signaling pathway

Combination of curcumin with HHT induced apoptosis and suppressed invasive ability of lymphoma cells. (A, B) U937 and Raji cells were treated with 5 ng/mL HHT or/and 10 μM curcumin for 72 h. Apoptotic cells were quantified by flow cytometry. (C, D) U937 and Raji cells were treated with 5 ng/mL HHT or/and 10 μM curcumin for 24 h. Cell invasion was assessed in a transwell invasion assay. (E, F) Cell migration was assessed in a transwell migration assay. **P ##P

Figure 2. Combination of curcumin with HHT induced apoptosis and suppressed invasive ability of lymphoma cells. (A, B) U937 and Raji cells were treated with 5 ng/mL HHT or/and 10 μM curcumin for 72 h. Apoptotic cells were quantified by flow cytometry. (C, D) U937 and Raji cells were treated with 5 ng/mL HHT or/and 10 μM curcumin for 24 h. Cell invasion was assessed in a transwell invasion assay. (E, F) Cell migration was assessed in a transwell migration assay. **P < 0.01 compared to control group; ##P < 0.01 compared to HHT group.