Research Paper Volume 13, Issue 15 pp 19475—19485

FK506 binding protein 10: a key actor of collagen crosslinking in clear cell renal cell carcinoma

FKBP10, PLOD2 and pro-collagen I shows high transcription level in ccRCC. Levels of FKBP10, PLOD2 and pro-collagen I mRNA were significantly higher in ccRCC than in normal tissue. Fold change, associated p values, and overexpression gene rank are shown. (A) FKBP10 mRNA expression level in Gumz Renal dataset. FKBP10 presented a fold change of 13.212, ranking top 2% in overexpression gene. (B) PLOD2 mRNA expression level in Gumz Renal dataset. PLOD2 presented a fold change of 4.249, ranking top 2% in overexpression gene. (C), (D) COL1A1 and COL1A2 mRNA expression level in Gumz Renal dataset. COL1A1 and COL1A2 presented a fold change of 3.850 and 9.055 respectively, both ranking top 2% in overexpression gene.

Figure 1. FKBP10, PLOD2 and pro-collagen I shows high transcription level in ccRCC. Levels of FKBP10, PLOD2 and pro-collagen I mRNA were significantly higher in ccRCC than in normal tissue. Fold change, associated p values, and overexpression gene rank are shown. (A) FKBP10 mRNA expression level in Gumz Renal dataset. FKBP10 presented a fold change of 13.212, ranking top 2% in overexpression gene. (B) PLOD2 mRNA expression level in Gumz Renal dataset. PLOD2 presented a fold change of 4.249, ranking top 2% in overexpression gene. (C), (D) COL1A1 and COL1A2 mRNA expression level in Gumz Renal dataset. COL1A1 and COL1A2 presented a fold change of 3.850 and 9.055 respectively, both ranking top 2% in overexpression gene.