Research Paper Volume 13, Issue 15 pp 19475—19485

FK506 binding protein 10: a key actor of collagen crosslinking in clear cell renal cell carcinoma

Gene Ontology analysis reports FKBP10 and its correlated genes are densely involved in collagen synthesis. (A) Molecular function analysis of FKBP10 in ccRCC: collagen binding (GO:0005518), extracellular matrix structural constituent conferring tensile strength (GO:0030020), cis-trans isomerase activity (GO:0016859). (B) Biological process analysis of FKBP10 in ccRCC: collagen fibril organization (GO:0030199), extracellular matrix organization (GO:0030198), peptidyl-proline modification (GO:0018208), peptidyl-lysine hydroxylation (GO:0017185), collagen metabolic process (GO:0032963). (C) Cellular component analysis of FKBP10 in ccRCC:: endoplasmic reticulum lumen (GO:0005788), endoplasmic reticulum (GO:0005783), collagen type I trimer (G:0005584), collagen trimer (GO:0005581), fibrillar collagen trimer (GO:0005583), banded collagen fibril (GO:0098643), complex of collagen trimers (GO:0098644).

Figure 5. Gene Ontology analysis reports FKBP10 and its correlated genes are densely involved in collagen synthesis. (A) Molecular function analysis of FKBP10 in ccRCC: collagen binding (GO:0005518), extracellular matrix structural constituent conferring tensile strength (GO:0030020), cis-trans isomerase activity (GO:0016859). (B) Biological process analysis of FKBP10 in ccRCC: collagen fibril organization (GO:0030199), extracellular matrix organization (GO:0030198), peptidyl-proline modification (GO:0018208), peptidyl-lysine hydroxylation (GO:0017185), collagen metabolic process (GO:0032963). (C) Cellular component analysis of FKBP10 in ccRCC:: endoplasmic reticulum lumen (GO:0005788), endoplasmic reticulum (GO:0005783), collagen type I trimer (G:0005584), collagen trimer (GO:0005581), fibrillar collagen trimer (GO:0005583), banded collagen fibril (GO:0098643), complex of collagen trimers (GO:0098644).