Research Paper Volume 13, Issue 15 pp 19908—19919

A circular RNA, circSMARCA5, inhibits prostate cancer proliferative, migrative, and invasive capabilities via the miR-181b-5p/miR-17-3p-TIMP3 axis

circSMARCA5 inhibits PC3 cell proliferative, migrative, and invasive capabilities. circSMARCA5 was upregulated or downregulated in PC3 cells. (A) The qRT-PCR results showed circSMARCA5 level in PC3 cells with indicated treatment. (B) PC3 cells’ growth with different treatments. The Transwell assay results showed the migration (C, D) and migration (C, E) of PC3 cells after indicated treatment. Magnification ×100. *, **, *** represent p ≤ 0.05, p ≤ 0.01, p ≤ 0.001, respectively. Assays were performed at least three times.

Figure 3. circSMARCA5 inhibits PC3 cell proliferative, migrative, and invasive capabilities. circSMARCA5 was upregulated or downregulated in PC3 cells. (A) The qRT-PCR results showed circSMARCA5 level in PC3 cells with indicated treatment. (B) PC3 cells’ growth with different treatments. The Transwell assay results showed the migration (C, D) and migration (C, E) of PC3 cells after indicated treatment. Magnification ×100. *, **, *** represent p ≤ 0.05, p ≤ 0.01, p ≤ 0.001, respectively. Assays were performed at least three times.