Research Paper Volume 13, Issue 15 pp 19908—19919

A circular RNA, circSMARCA5, inhibits prostate cancer proliferative, migrative, and invasive capabilities via the miR-181b-5p/miR-17-3p-TIMP3 axis

circSMARCA5 suppresses proliferative and invasive potential via the miR-181b-5p/miR-17-3p-TIMP3 axis. (A, B) circSMARCA5 overexpressing vectors were transfected into DU145 cells with and without miR-17-3p mimic. Cell proliferation, migration, and invasion were determined. (C, D) circSMARCA5 overexpressing vectors were transfected into DU145 cells with and without miR-181b-5p mimic. Cell proliferation, migration, and invasion were measured. *, **, *** represent p ≤ 0.05, p ≤ 0.01, p ≤ 0.001, respectively. Assays were performed at least three times.

Figure 6. circSMARCA5 suppresses proliferative and invasive potential via the miR-181b-5p/miR-17-3p-TIMP3 axis. (A, B) circSMARCA5 overexpressing vectors were transfected into DU145 cells with and without miR-17-3p mimic. Cell proliferation, migration, and invasion were determined. (C, D) circSMARCA5 overexpressing vectors were transfected into DU145 cells with and without miR-181b-5p mimic. Cell proliferation, migration, and invasion were measured. *, **, *** represent p ≤ 0.05, p ≤ 0.01, p ≤ 0.001, respectively. Assays were performed at least three times.