Research Paper Volume 13, Issue 16 pp 20277—20301

Comprehensive analysis of ubiquitin-proteasome system genes related to prognosis and immunosuppression in head and neck squamous cell carcinoma

Differential expression of UPS-related genes (UPSGs) and identification of 8 UPSGs with prognostic value in HNSCC samples. (A) 114 differentially expressed UPSGs (DEUPSGs) are depicted as a heat map. (B) 97 upregulated and 17 downregulated DEUPSGs are shown as a volcano plot (FDR  1.5). (C) The eight risk DEUPSGs in the prognostic risk model are shown using a forest plot.

Figure 1. Differential expression of UPS-related genes (UPSGs) and identification of 8 UPSGs with prognostic value in HNSCC samples. (A) 114 differentially expressed UPSGs (DEUPSGs) are depicted as a heat map. (B) 97 upregulated and 17 downregulated DEUPSGs are shown as a volcano plot (FDR < 0.05 and |Fold change| > 1.5). (C) The eight risk DEUPSGs in the prognostic risk model are shown using a forest plot.