Research Paper Volume 13, Issue 16 pp 20716—20737

N6-methyladenosine (m6A) modification and its clinical relevance in cognitive dysfunctions

Mutation frequency distribution of m6A regulators across different groups in brain and blood samples. (A) Unsupervised clustering of 26 m6A regulators in GSE122063, annotated according to cognitive statues. Red represented high expression of regulators and blue represented low expression. (B) Unsupervised clustering of 26 m6A regulators in GSE63060 and GSE636061, annotated according to cognitive statues. Yellow represented high expression of regulators and blue represented low expression. (C–D) The expression profiles of 26 m6A regulators in brain and blood samples. (E–L) Box plots showing representative expression differences between CTL, VD and AD from brain sample, or between CTL, MCI and AD from blood sample. *p **p ***p ****p

Figure 2. Mutation frequency distribution of m6A regulators across different groups in brain and blood samples. (A) Unsupervised clustering of 26 m6A regulators in GSE122063, annotated according to cognitive statues. Red represented high expression of regulators and blue represented low expression. (B) Unsupervised clustering of 26 m6A regulators in GSE63060 and GSE636061, annotated according to cognitive statues. Yellow represented high expression of regulators and blue represented low expression. (CD) The expression profiles of 26 m6A regulators in brain and blood samples. (EL) Box plots showing representative expression differences between CTL, VD and AD from brain sample, or between CTL, MCI and AD from blood sample. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, ns: no significance.