Research Paper Volume 13, Issue 17 pp 21587—21598

FOXN3 inhibits cell proliferation and invasion via modulating the AKT/MDM2/p53 axis in human glioma

Decreased FOXN3 expression is observed in glioma tissues. (A) FOXN3 mRNA expression levels in clinical tissue samples were determined via qPCR analysis. (B) FOXN3 protein expression levels in clinical tissue samples were examined using Western blotting. (C) Glioma patients were divided into high FOXN3 expression group and low FOXN3 expression group based on the median of its expression levels in cancerous tissues. Kaplan-Meier survival curve was used to analyze the correlation between FOXN3 mRNA expression level and overall survival time. **P

Figure 1. Decreased FOXN3 expression is observed in glioma tissues. (A) FOXN3 mRNA expression levels in clinical tissue samples were determined via qPCR analysis. (B) FOXN3 protein expression levels in clinical tissue samples were examined using Western blotting. (C) Glioma patients were divided into high FOXN3 expression group and low FOXN3 expression group based on the median of its expression levels in cancerous tissues. Kaplan-Meier survival curve was used to analyze the correlation between FOXN3 mRNA expression level and overall survival time. **P < 0.01. Abbreviation: FOXN3: forkhead box N3.