Research Paper Volume 13, Issue 17 pp 21587—21598

FOXN3 inhibits cell proliferation and invasion via modulating the AKT/MDM2/p53 axis in human glioma

FOXN3 over-expression retards glioma cell growth in vivo. (A) Representative images of tumors harvested from murine neoplasm xenograft models. (B) Tumor growth curve was plotted based on the formula that volume (mm3) = [length (mm) × width2 (mm2)]/2. (C) Neoplasms were collected and weighed at day 28 post-transplantation. (D) Protein expression patterns of Ki67, cleaved caspase 3 and Vimentin in the tumors harvested from nude mice were visualized via immunohistochemical staining. **P

Figure 5. FOXN3 over-expression retards glioma cell growth in vivo. (A) Representative images of tumors harvested from murine neoplasm xenograft models. (B) Tumor growth curve was plotted based on the formula that volume (mm3) = [length (mm) × width2 (mm2)]/2. (C) Neoplasms were collected and weighed at day 28 post-transplantation. (D) Protein expression patterns of Ki67, cleaved caspase 3 and Vimentin in the tumors harvested from nude mice were visualized via immunohistochemical staining. **P < 0.01. Abbreviation: FOXN3: forkhead box N3.