COVID-19 Research Paper Volume 13, Issue 17 pp 20860—20885

Circulating acetylated polyamines correlate with Covid-19 severity in cancer patients

Integration of metabolic with inflammatory markers in serum samples from cancer patients with different levels of Covid-19 severity. The correlation heatmap of data was generated by means of Pearson’s method, and clustered using the ward. D2 method. The red color indicates positive correlations with a FDR0.05) associations. *p

Figure 6. Integration of metabolic with inflammatory markers in serum samples from cancer patients with different levels of Covid-19 severity. The correlation heatmap of data was generated by means of Pearson’s method, and clustered using the ward. D2 method. The red color indicates positive correlations with a FDR<0.05, and the green color marks negative correlations with FDR<0.05. Black indicates non-significant (FDR>0.05) associations. *p < 0.05, **p < 0.01, ***p < 0.001. TNFα: tumor necrosis factor alpha. GzB: Granzyme B. TNFα on GzB in CD8 is the ratio between soluble TNFα and GzB in CD8+ T cells (by flow cytometry) and IFNγ on GzB in CD8 is the ratio between soluble IFNγ GzB in CD8+ T cells (by flow cytometry).