Research Paper Volume 13, Issue 21 pp 24402—24416

miR-6745-TIMP1 axis inhibits cell growth and metastasis in gastric cancer

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Figure 6.

miR-6745-TIMP1 axis regulates Wnt/β-catenin signaling in GC cells. (A, B) β-catenin reporter assay in SGC-7901 and MGC-803 cells with TIMP1 overexpression (A) or miR-340 overexpression (B). (C, D) Effects of miR-6745 on protein levels of total β-catenin, phosphorylated β-catenin (Ser33/37/Thr41), cyclin D1, E-cadherin and N-cadherin. (E, F) TIMP1 partially restored the levels of total β-catenin, phosphorylated β-catenin (Ser33/37/Thr41), cyclin D1, E-cadherin and N-cadherin. Data represent the means ± SEM. **P < 0.01.