Research Paper Volume 13, Issue 23 pp 25564—25577
CHIP ameliorates cerebral ischemia-reperfusion injury by attenuating necroptosis and inflammation
Figure 5. CHIP overexpression attenuated necroptosis induced by MCAO. (A) Western blot of RIPK1, p-RIPK3, RIPK3, p-MLKL, MLKL, and CHIP in the peri-infarct tissues after MCAO. (B–F) Quantitative analysis of RIPK1, p-RIPK3, RIPK3, p-MLKL, and MLKL in the peri-infarct tissues after MCAO. (G) Quantitative analysis of CHIP. Data are presented as the mean ± SEM; n=6/group; ns, no significant difference; *P < 0.05.