Research Paper Volume 14, Issue 24 pp 9980—10008

Figure 5. The correlation of infiltration levels of six types of immune cell types with NLRP1/NLRP3 expression levels and survival in STAD (n = 415) in TIMER 2.0. (A) NLRP1 expression level is significantly negatively related to tumor purity and has a significantly positive correlation with the abundance of all 6 types of immune cells in STAD (all p < 0.001). (B) NLRP3 expression is significantly negatively related to tumor purity and has a significant positive correlation with 5 types of immune cells (CD8+ T cells, CD4+ T cells, macrophages, neutrophils, and dendritic cells, other than B cells) in STAD (p < 0.001). (C) In six types of immune cell, the infiltration level of macrophage was significantly correlated with the cumulative survival of patients of STAD (p = 0.004).