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Page: 123 of 3

• Research PaperVolume 10, Issue 6pp 1306-1323

  Loss of NAMPT in aging retinal pigment epithelium reduces NAD⁺ availability and promotes cellular senescence

  Relevance score: 0.00

  Ravirajsinh N. Jadeja, Folami L. Powell, Malita A. Jones, Jasmine Fuller, Ethan Joseph, Menaka C. Thounaojam, Manuela Bartoli, Pamela M. Martin

  Keywords: retinal pigment epithelium (RPE), aging, age-related macular degeneration (AMD), NAD+, NAMPT, senescence, SIRT1

  Published in Aging on June 12, 2018

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• Research PaperVolume 17, Issue 3pp 657-684

  Deciphering age-related transcriptomic changes in the mouse retinal pigment epithelium

  Relevance score: 0.00

  Sushil K. Dubey, Rashmi Dubey, Kyungsik Jung, Alvaro G. Hernandez, Mark E. Kleinman

  Keywords: transcriptome, retinal pigment epithelium, oxidative stress, inflammation, chronological aging

  Published in Aging on March 4, 2025

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• Research PaperVolume 13, Issue 8pp 11010-11025

  Obacunone protects retinal pigment epithelium cells from ultra-violet radiation-induced oxidative injury

  Relevance score: 0.00

  Da-Rui Huang, Chang-Ming Dai, Shu-Yan Li, Xiao-Feng Li

  Keywords: obacunone, UV radiation, retinal pigment epithelium cells, Nrf2 signaling, oxidative injury

  Published in Aging on February 1, 2021

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• Research PaperVolume 3, Issue 1pp 44-54

  Alterations of retinal pigment epithelium cause AMD-like retinopathy in senescence-accelerated OXYS rats

  Relevance score: 0.00

  Anton M. Markovets, Valeriya B. Saprunova, Anna A. Zhdankina, Anzhella Zh. Fursova, Lora E. Bakeeva, Natalia G. Kolosova

  Keywords: age-related macular degeneration, OXYS rats, molecular mechanism of pathogenesis, vascular endothelial growth factor, pigment epithelium-derived factor

  Published in Aging on December 12, 2010

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• Research PaperVolume 16, Issue 4pp 3955-3972

  Protective effects of triptolide against oxidative stress in retinal pigment epithelium cells via the PI3K/AKT/Nrf2 pathway: a network pharmacological method and experimental validation

  Relevance score: 0.00

  Fuying Pan, Qinxin Shu, Hao Xie, Long Zhao, Ping Wu, Yong Du, Jing Lu, Yuxia He, Xing Wang, Hui Peng

  Keywords: triptolide, oxidative stress, PI3K/Akt/Nrf2 pathway, network pharmacological analysis

  Published in Aging on February 21, 2024

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• Research PaperVolume 10, Issue 6pp 1380-1389

  The expression of C1 inhibitor (C1INH) in macrophages is upregulated by retinal pigment epithelial cells – implication in subretinal immune privilege in the aging eye

  Relevance score: 0.00

  Chang Luo, Jiawu Zhao, Mei Chen, Heping Xu

  Keywords: macrophages, retinal pigment epithelial cells, complement, aging, subretinal immune privilege

  Published in Aging on June 13, 2018

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• Research PaperVolume 10, Issue 11pp 3173-3184

  Effects of senescent secretory phenotype acquisition on human retinal pigment epithelial stem cells

  Relevance score: 0.00

  Raffaella Lazzarini, Michele Nicolai, Vittorio Pirani, Cesare Mariotti, Roberto Di Primio

  Keywords: AMD, RPESCs, age-related diseases, senescence, inflammation

  Published in Aging on November 16, 2018

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• Research PaperVolume 15, Issue 6pp 1713-1733

  Knockout of AMD-associated gene POLDIP2 reduces mitochondrial superoxide in human retinal pigment epithelial cells

  Relevance score: 0.00

  Tu Nguyen, Daniel Urrutia-Cabrera, Luozixian Wang, Jarmon G. Lees, Jiang-Hui Wang, Sandy S.C. Hung, Alex W. Hewitt, Thomas L. Edwards, Sam McLenachan, Fred K. Chen, Shiang Y. Lim, Chi D. Luu, Robyn Guymer, Raymond C.B. Wong

  Keywords: age-related macular degeneration, retina, CRISPR/Cas, mitochondria superoxide, POLDIP2

  Published in Aging on February 16, 2023

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• Research PaperVolume 13, Issue 18pp 22040-22058

  A2E-induced inflammation and angiogenesis in RPE cells in vitro are modulated by PPAR-α, -β/δ, -γ, and RXR antagonists and by norbixin

  Relevance score: 0.00

  Valérie Fontaine, Mylène Fournié, Elodie Monteiro, Thinhinane Boumedine, Christine Balducci, Louis Guibout, Mathilde Latil, José-Alain Sahel, Stanislas Veillet, Pierre J. Dilda, René Lafont, Serge Camelo

  Keywords: N-retinylidene-N-retinylethanolamine (A2E), norbixin, peroxisome proliferator-activated receptor (PPAR), retinal pigment epithelium (RPE), retinoic X receptor (RXR)

  Published in Aging on September 20, 2021

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• Research PaperVolume 12, Issue 14pp 13905-13923

  Activation of C-reactive protein proinflammatory phenotype in the blood retinal barrier in vitro: implications for age-related macular degeneration

  Relevance score: 0.00

  Sara Romero-Vázquez, Alfredo Adán, Marc Figueras-Roca, Victor Llorenç, Mark Slevin, Gemma Vilahur, Lina Badimon, Andrew D Dick, Blanca Molins

  Keywords: age-related macular degeneration, retinal pigment epithelium, inflammation, C-reactive protein

  Published in Aging on July 16, 2020

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• Research PaperVolume 11, Issue 13pp 4323-4337

  HMGB1 and Caveolin-1 related to RPE cell senescence in age-related macular degeneration

  Relevance score: 0.00

  Shuo Sun, Bincui Cai, Yao Li, Wenqi Su, Xuzheng Zhao, Boteng Gong, Zhiqing Li, Xiaomin Zhang, Yalin Wu, Chao Chen, Stephen H. Tsang, Jin Yang, Xiaorong Li

  Keywords: A2E, HMGB1, Caveolin-1, RPE cell senescence, AMD

  Published in Aging on July 7, 2019

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• Research PaperVolume 12, Issue 16pp 16579-16596

  Suppressing endoplasmic reticulum stress-related autophagy attenuates retinal light injury

  Relevance score: 0.00

  Jing-Yao Song, Bin Fan, Lin Che, Yi-Ran Pan, Si-Ming Zhang, Ying Wang, Victoria Bunik, Guang-Yu Li

  Keywords: oxidative stress, ER stress, autophagy, AMD, PERK

  Published in Aging on August 28, 2020

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• Research PaperVolume 5, Issue 6pp 427-444

  Deficiency in the metabolite receptor SUCNR1 (GPR91) leads to outer retinal lesions

  Relevance score: 0.00

  Sandra Favret, Francois Binet, Eric Lapalme, Dominique Leboeuf, Jose Carbadillo, Tina Rubic, Emilie Picard, Gaelle Mawambo, Nicolas Tetreault, Jean-Sebastien Joyal, Sylvain Chemtob, Florian Sennlaub, John Paul SanGiovanni, Martin Guimond, Przemyslaw Sapieha

  Keywords: AMD, GPR91, geographic atrophy, microglia, succinate, metabolite receptor

  Published in Aging on June 17, 2013

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• Research PaperVolume 2, Issue 12pp 981-989

  CD36 plays an important role in the clearance of oxLDL and associated age-dependent sub-retinal deposits

  Relevance score: 0.00

  Emilie Picard, Marianne Houssier, Kim Bujold, Przemyslaw Sapieha, William Lubell, Allison Dorfman, Julie Racine, Pierre Hardy, Maria Febbraio, Pierre Lachapelle, Huy Ong, Florian Sennlaub, Sylvain Chemtob

  Keywords: CD36, oxidized lipids, Bruch's membrane, age-related macular degeneration

  Published in Aging on November 9, 2010

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• Research PaperVolume 13, Issue 8pp 10866-10890

  Pharmacologic activation of autophagy without direct mTOR inhibition as a therapeutic strategy for treating dry macular degeneration

  Relevance score: 0.00

  Qitao Zhang, Feriel Presswalla, Robin R. Ali, David N. Zacks, Debra A. Thompson, Jason ML. Miller

  Keywords: age-related macular degeneration (AMD), drusen, lipofuscin, retinal pigment epithelium (RPE), autophagy

  Published in Aging on April 19, 2021

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• Research PerspectiveVolume 1, Issue 8pp 740-745

  What determines the switch between atrophic and neovascular forms ofage related macular degeneration? - the role of BMP4 induced senescence

  Relevance score: 0.00

  DanHong Zhu, Xuemei Deng, Jing Xu, David R Hinton

  Keywords: BMP4, age related macular degeneration, senescence, retinal pigment epithelial cell, oxidative stress

  Published in Aging on August 12, 2009

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• Research PaperVolume 12, Issue 7pp 6151-6171

  Systemic administration of the di-apocarotenoid norbixin (BIO201) is neuroprotective, preserves photoreceptor function and inhibits A2E and lipofuscin accumulation in animal models of age-related macular degeneration and Stargardt disease

  Relevance score: 0.00

  Valérie Fontaine, Elodie Monteiro, Mylène Fournié, Elena Brazhnikova, Thinhinane Boumedine, Cécile Vidal, Christine Balducci, Louis Guibout, Mathilde Latil, Pierre J. Dilda, Stanislas Veillet, José-Alain Sahel, René Lafont, Serge Camelo

  Keywords: norbixin, retinal function, A2E, AMD, Stargardt disease

  Published in Aging on April 7, 2020

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• Research PaperVolume 16, Issue 6pp 5435-5451

  Identification of key lncRNAs in age-related macular degeneration through integrated bioinformatics and experimental validation

  Relevance score: 0.00

  Yuying Ji, Chengguo Zuo, Nanying Liao, Liwei Yao, Ruijun Yang, Hui Chen, Feng Wen

  Keywords: noncoding RNA, age-related macular degeneration, bioinformatics, LINC00276, senescence

  Published in Aging on March 14, 2024

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• Research PaperVolume 6, Issue 12pp 1064-1075

  Pathway activation profiling reveals new insights into Age-related Macular Degeneration and provides avenues for therapeutic interventions

  Relevance score: 0.00

  Evgeny Makarev, Charles Cantor, Alex Zhavoronkov, Anton Buzdin, Alexander Aliper, Antonei Benjamin Csoka

  Keywords: AMD, Age-related Macular Degeneration, gene expression, Transcriptome profiling, signaling pathway activation strength

  Published in Aging on December 22, 2014

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• Research PaperVolume 15, Issue 1pp 37-52

  Genetic deficiency and pharmacological modulation of RORα regulate laser-induced choroidal neovascularization

  Relevance score: 0.00

  Chi-Hsiu Liu, Felix Yemanyi, Kiran Bora, Neetu Kushwah, Alexandra K. Blomfield, Theodore M. Kamenecka, John Paul SanGiovanni, Ye Sun, Laura A. Solt, Jing Chen

  Keywords: age-related macular degeneration, angiogenesis, choroidal neovascularization, inflammation, nuclear receptors, RORα, VEGFR2, TNFα

  Published in Aging on January 10, 2023

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