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Online ISSN: 1945-4589
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10-25-2021
Aging-US published " Applying deductive reasoning and the principles of particle physics to aging research " which reported that aging research currently lacks a common conceptual framework, and one challenge in establishing it is the fact that aging is a highly complex process. To help develop a framework of standard…
10-25-2021
Aging-US published " Helicobacter pylori infection and risk for developing dementia: an evidence-based meta-analysis of case-control and cohort studies " which reported that infection with multiple pathogens may play a key role in the pathogenesis of dementia. Whether Helicobacter pylori infection is associated…
10-25-2021
Aging-US published " Melatonin inhibits proliferation, migration, and invasion by inducing ROS-mediated apoptosis via suppression of the PI3K/Akt/mTOR signaling pathway in gallbladder cancer cells " which reported that melatonin is an indolic compound mainly secreted by the pineal gland and plays a vital role in the…
10-25-2021
Aging-US published " Development of infrastructure for a systemic multidisciplinary approach to study aging in retired sled dogs " which reported that canines represent a valuable model for mammalian aging studies as large animals with short lifespans, allowing longitudinal analyses within a reasonable time frame.…
10-25-2021
Aging-US published " Iron: an underrated factor in aging " which reported that iron is an essential element for virtually all living organisms, but its reactivity also makes it potentially harmful. Blocking iron absorption through drugs or natural products extends lifespan. Dr. Dennis Mangan from MTOR LLC in…
10-25-2021
Aging-US published " Green tea catechins EGCG and ECG enhance the fitness and lifespan of Caenorhabditis elegans by complex I inhibition " which reported that green tea catechins are associated with a delay in aging. The authors have designed the current study to investigate the impact and to unveil the target of the…
10-25-2021
Aging-US published " Involvement of cerebrovascular abnormalities in the pathogenesis and progression of Alzheimer’s disease: an adrenergic approach " which reported that alzheimer’s disease, as the most common neurodegenerative disease in elder population, is pathologically characterized by β-amyloid plaques,…
09-21-2021
Aging-US published " Cellular senescence in lymphoid organs and immunosenescence " which reported that immunosenescence is a multi-faceted phenomenon at the root of age-associated immune dysfunction. Though both cellular senescence and immunosenescence have been studied extensively and implicated in various…
09-21-2021
Aging-US published " The role of age at menarche and age at menopause in Alzheimer’s disease: evidence from a bidirectional mendelian randomization study " which reported that the association between endogenous estrogen exposure and Alzheimer’s disease remains inconclusive in previous observational studies, and few…
09-21-2021
Aging-US published " Senescence-associated hyper-activation to inflammatory stimuli in vitro " which reported that aging is associated with an increased susceptibility to adverse inflammatory conditions such as sepsis and cytokine storm. To test this hypothesis, the authors examined the expression of various…
09-21-2021
Aging-US published " N6-methyladenosine (m6A) modification and its clinical relevance in cognitive dysfunctions " which reported that the authors systematically investigated the molecular alterations of m6A regulators and their clinical relevance with cognitive dysfunctions using published datasets of Alzheimer's…
09-21-2021
Aging-US published " Proteomic characterization of secretory granules in dopaminergic neurons indicates chromogranin/secretogranin-mediated protein processing impairment in Parkinson’s disease " which reported that the number of SGs in tyrosine hydroxylase-positive neurons and the marker proteins secretogranin III…
09-21-2021
Aging-US published " Reduced uremic metabolites are prominent feature of sarcopenia, distinct from antioxidative markers for frailty " which reported that due to global aging, frailty and sarcopenia are increasing. Sarcopenia is defined as loss of volume and strength of skeletal muscle in elderlies, while frailty…
09-21-2021
Aging-US published " The interplay between gray matter and white matter neurodegeneration in subjective cognitive decline " which reported that subjective cognitive complaints were assessed through 9 questions covering amnestic and non-amnestic cognitive domains. In these author’s cohort, 123 individuals endorsed from…
09-08-2021
Aging-US published a Special Collection on Eye Disease which included " Age-related changes in eye lens biomechanics, morphology, refractive index and transparency " which reported that life-long eye lens function requires an appropriate gradient refractive index, biomechanical integrity and transparency. The authors…
09-08-2021
Aging-US published a Special Collection on Eye Disease which included " Activation of C-reactive protein proinflammatory phenotype in the blood retinal barrier in vitro: implications for age-related macular degeneration " which reported that the retinal pigment epithelium (RPE) is considered one of the main targets of…
09-08-2021
Aging-US published a Special Collection on Eye Disease which included " PU-91 drug rescues human age-related macular degeneration RPE cells; implications for AMD therapeutics " which reported that the PU-91 drug upregulates PGC-1α which is a critical regulator of mitochondrial biogenesis. Since mitochondrial…
09-08-2021
Aging-US published a Special Collection on Eye Disease which included " Effects of senescent secretory phenotype acquisition on human retinal pigment epithelial stem cells " which reported that loss of retinal pigment epithelium (RPE) cells occurs early in AMD, and their transplant has the potential to slow disease…
09-08-2021
Aging-US published a Special Collection on Eye Disease which included " Nutraceutical effects of Emblica officinalis in age-related macular degeneration " which reported that EO has been used extensively as a nutraceutical in several diseases since it is known to boost immunity and offers numerous health benefits such…
09-08-2021
Aging-US published a Special Collection on Eye Disease which included " p62 /SQSTM1 coding plasmid prevents age related macular degeneration in a rat model " which reported that P62/SQSTM1, a multi-domain protein that regulates inflammation, apoptosis, and autophagy, has been linked to age-related pathologies. In…