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Online ISSN: 1945-4589
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09-21-2021
Aging-US published " Proteomic characterization of secretory granules in dopaminergic neurons indicates chromogranin/secretogranin-mediated protein processing impairment in Parkinson’s disease " which reported that the number of SGs in tyrosine hydroxylase-positive neurons and the marker proteins secretogranin III…
09-21-2021
Aging-US published " The role of age at menarche and age at menopause in Alzheimer’s disease: evidence from a bidirectional mendelian randomization study " which reported that the association between endogenous estrogen exposure and Alzheimer’s disease remains inconclusive in previous observational studies, and few…
09-08-2021
Aging-US published a Special Collection on Eye Disease which included "Suppressing endoplasmic reticulum stress-related autophagy attenuates retinal light injury" which reported that in this study, oxidative stress, endoplasmic reticulum stress and autophagy caused by light exposure were evaluated in vitro and in…
09-08-2021
Aging-US published a Special Collection on Eye Disease which included " A comprehensive evaluation of 181 reported CHST6 variants in patients with macular corneal dystrophy " which reported that macular corneal dystrophy is an autosomal recessive disease featured by bilateral progressive stromal clouding and loss of…
09-08-2021
Aging-US published a Special Collection on Eye Disease which included " miR-106b suppresses pathological retinal angiogenesis " which reported that microRNAs are small non-coding RNAs that post-transcriptionally regulate gene expression. Here, the authors show that expression of the miR-106b-25 cluster is negatively…
09-08-2021
Aging-US published a Special Collection on Eye Disease which included " Abnormalities of saccadic eye movements in dementia due to Alzheimer’s disease and mild cognitive impairment " which reported that there is increasing evidence that people in the early stages of Alzheimer’s disease have subtle impairments in…
09-08-2021
Aging-US published a Special Collection on Eye Disease which included " PU-91 drug rescues human age-related macular degeneration RPE cells; implications for AMD therapeutics " which reported that the PU-91 drug upregulates PGC-1α which is a critical regulator of mitochondrial biogenesis. Since mitochondrial…
09-08-2021
Aging-US published a Special Collection on Eye Disease which included " Age-related changes in eye lens biomechanics, morphology, refractive index and transparency " which reported that life-long eye lens function requires an appropriate gradient refractive index, biomechanical integrity and transparency. The authors…
09-08-2021
Aging-US published a Special Collection on Eye Disease which included " Systemic administration of the di-apocarotenoid norbixin (BIO201) is neuroprotective, preserves photoreceptor function and inhibits A2E and lipofuscin accumulation in animal models of age-related macular degeneration and Stargardt disease " which…
09-08-2021
Aging-US published a Special Collection on Eye Disease which included " HMGB1 and Caveolin-1 related to RPE cell senescence in age-related macular degeneration " and reported that AMD is a major unmet medical need as it is estimated that more than 20 million patients will be affected by 2050 in the US alone. STGD is…
09-08-2021
Aging-US published a Special Collection on Eye Disease which included " Exploration of age-related mitochondrial dysfunction and the anti-aging effects of resveratrol in zebrafish retina " which reported that resveratrol was shown to not only increase mitochondrial quality and function, but also to suppress Akt/mTOR…
09-08-2021
Aging-US published a Special Collection on Eye Disease which included " Activation of C-reactive protein proinflammatory phenotype in the blood retinal barrier in vitro: implications for age-related macular degeneration " which reported that the retinal pigment epithelium (RPE) is considered one of the main targets of…
09-08-2021
Aging-US published a Special Collection on Eye Disease which included " Role of Citicoline in an in vitro AMD model " which reported that citicoline is the exogenous form of the nootropic, Cytidine 5'-diphosphate-choline that exerts its neuroprotective effects in the brain as well as in the eye. Citicoline alleviates…
09-08-2021
Aging-US published a Special Collection on Eye Disease which included " Effects of senescent secretory phenotype acquisition on human retinal pigment epithelial stem cells " which reported that loss of retinal pigment epithelium (RPE) cells occurs early in AMD, and their transplant has the potential to slow disease…
09-08-2021
Aging-US published a Special Collection on Eye Disease which included " p62 /SQSTM1 coding plasmid prevents age related macular degeneration in a rat model " which reported that P62/SQSTM1, a multi-domain protein that regulates inflammation, apoptosis, and autophagy, has been linked to age-related pathologies. In…
09-08-2021
Aging-US published a Special Collection on Eye Disease which included " Immunological analyses reveal an immune subtype of uveal melanoma with a poor prognosis " which reported that uveal melanoma is an aggressive intraocular malignancy that often exhibits low immunogenicity. Metastatic uveal Melanoma samples…
09-08-2021
Aging-US published a Special Collection on Eye Disease which included " Nutraceutical effects of Emblica officinalis in age-related macular degeneration " which reported that EO has been used extensively as a nutraceutical in several diseases since it is known to boost immunity and offers numerous health benefits such…
09-08-2021
Aging-US published a Special Collection on Eye Disease which included " Loss of macroH2A1 decreases mitochondrial metabolism and reduces the aggressiveness of uveal melanoma cells " which reported that uveal melanoma (UM) is the most common primary intraocular tumour in adults. Most accurate prognostic factor of UM is…
09-08-2021
Aging-US published a Special Collection on Eye Disease which included " ALKBH5-mediated m6A demethylation of FOXM1 mRNA promotes progression of uveal melanoma " which reported that ALKBH5, a key component of the N6-methyladenosine (m6A) methyltransferase complex, was significantly elevated in uveal melanoma cell lines…
09-08-2021
Aging-US published a Special Collection on Eye Disease which included " The expression of C1 inhibitor (C1INH) in macrophages is upregulated by retinal pigment epithelial cells – implication in subretinal immune privilege in the aging eye " which reported that this study aimed to understand how complement expression…