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Online ISSN: 1945-4589
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08-09-2021
Aging-US published “ Acid ceramidase promotes senescent cell survival ” which reported that the authors identified acid ceramidase (ASAH1), a lysosomal enzyme that cleaves ceramide into sphingosine and fatty acid, as being highly elevated in senescent cells. This increase in ASAH1 levels in senescence is associated…
08-09-2021
Aging-US published " A model of the aged lung epithelium in idiopathic pulmonary fibrosis " which reported that Iiopathic pulmonary fibrosis (IPF) is an age-related disorder that carries a universally poor prognosis. By exposing mouse alveolar epithelial cells to repeated, low doses of bleomycin, instead of usual…
08-09-2021
Aging-US published " Beneficial effects of dietary supplementation with green tea catechins and cocoa flavanols on aging-related regressive changes in the mouse neuromuscular system " which reported that green tea extract (GTE) and cocoa-supplemented diets significantly improved survival rate of mice. GTE increased…
07-25-2021
Aging-US published " Differential responses of neurons, astrocytes, and microglia to G-quadruplex stabilization " which reported that while it is now firmly established that stabilized G4s lead to enhanced genomic instability in cancer cells, whether and how G4s contribute to genomic instability in brain cells is…
07-25-2021
Aging-US published " PirB functions as an intrinsic suppressor in hippocampal neural stem cells " which reported that neural stem cells play pivotal roles during prenatal development and throughout life. PirB expression increased with age during development, and its deficiency promoted neural stem cell proliferation…
07-25-2021
Aging-US published " HMGA1 promotes gastric cancer growth and metastasis by transactivating SUZ12 and CCDC43 expression " which reported that HMGA1 is overexpressed in GC cells and the high expression of HMGA1 was correlated with worse survival in GC patients using a bioinformatics assay. Functionally, HMGA1 affected…
07-25-2021
Aging-US published " Identification of microenvironment related potential biomarkers of biochemical recurrence at 3 years after prostatectomy in prostate adenocarcinoma " which reported that the authors aimed to identify the potential prognostic genes in the prostate adenocarcinoma microenvironment and to estimate the…
07-25-2021
Aging-US published " Calycosin inhibits breast cancer cell migration and invasion by suppressing EMT via BATF/TGF-β1 " which reported that in this study, the authors investigated the effects of calycosin on breast cancer cell progression and their underlying mechanisms. Calycosin dose- and time-dependently inhibited…
07-25-2021
Aging-US published " Comprehensive analysis of the competing endogenous circRNA-lncRNA-miRNA-mRNA network and identification of a novel potential biomarker for hepatocellular carcinoma " which reported that there is still a lack of comprehensive analysis of the circular RNA -long non-coding RNA -miRNA-mRNA ceRNA…
07-25-2021
Aging-US published " Antrodia salmonea induces apoptosis and enhances cytoprotective autophagy in colon cancer cells " which reported that 3- -2,5-diphenyltetrazolium bromide assay revealed that AS showed a remarkable effect on cell viability in colon cancer cells; SW620, HCT116, and HT29. Annexin V/propidium iodide…
07-25-2021
Aging-US published " Cognition and action: a latent variable approach to study contributions of executive functions to motor control in older adults " which reported that Aging is associated with profound alterations in motor control that may be exacerbated by age-related executive functioning decline. However,…
07-25-2021
Aging-US published " miRNAs generated from Meg3-Mirg locus are downregulated during aging " which reported that Aging determines a multilevel functional decline and increases the risk for cardiovascular pathologies. The heart is one of the most affected organs in aged individuals, however little is known about the…
07-25-2021
Aging-US published " The lack of functional DNMT2/TRDMT1 gene modulates cancer cell responses during drug-induced senescence " which reported that cellular senescence may be a side effect of chemotherapy and other anti-cancer treatments that may promote inflammation and paracrine secondary senescence in healthy…
07-25-2021
Aging-US published " Spatiotemporal dynamics of γH2AX in the mouse brain after acute irradiation at different postnatal days with special reference to the dentate gyrus of the hippocampus " which reported that, radiosensitivity of the different brain cells, including neurons, glial cells, cells in cerebrovascular…
07-25-2021
Aging-US published " MiR-513b-5p represses autophagy during the malignant progression of hepatocellular carcinoma by targeting PIK3R3 " which reported MiR-513b-5p repressed liver cancer cell proliferation, migration/invasion, and induced apoptosis in vitro. Crucially, miR-513b-5p attenuated tumor growth of liver…
07-25-2021
Aging-US published " Identification of RNA binding protein interacting with circular RNA and hub candidate network for hepatocellular carcinoma " which reported that 17 DERBPs, which were commonly dysregulated in HCC from The Clinical Proteomic Tumor Analysis Consortium, The Cancer Genome Atlas and International…
07-25-2021
Aging-US published " PTEN nuclear translocation enhances neuronal injury after hypoxia-ischemia via modulation of the nuclear factor-κB signaling pathway " which reported that this study was designed to investigate phosphatase and tensin homolog nuclear translocation and its possible role in rat cortical neuronal…
07-25-2021
Aging-US published " A novel ferroptosis-related gene signature for prognostic prediction of patients with lung adenocarcinoma " which reported that RNA-seq transcriptome data of LUAD patients were obtained from The Cancer Genome Atlas database. Kaplan–Meier survival and receiver operating characteristic curves were…
07-25-2021
Aging-US published " Facility-based and home-based multidomain interventions including cognitive training, exercise, diet, vascular risk management, and motivation for older adults: a randomized controlled feasibility trial " which reported that in an outcome assessor-blinded, randomized controlled trial, participants…
07-25-2021
Aging-US published " A novel ferroptosis-related gene signature for prognostic prediction of patients with lung adenocarcinoma " which reported that RNA-seq transcriptome data of LUAD patients were obtained from The Cancer Genome Atlas database. Kaplan–Meier survival and receiver operating characteristic curves were…