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Online ISSN: 1945-4589
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08-25-2019
Leukocyte DNAm TL is applicable across the entire age spectrum and is more strongly associated with age than measured leukocyte TL. Leukocyte DNAm TL outperforms LTL in predicting: i)time-to-death, ii)time-to-coronary heart disease, iii)time-to-congestive heart failure and iv)association with smoking history. Dr.…
08-25-2019
In this study, the research team conducted a large-scale epigenome-wide association study of LTL using seven large cohorts the Framingham Heart Study, the Jackson Heart Study, the Womens Health Initiative, the Bogalusa Heart Study, the Lothian Birth Cohorts of 1921 and 1936, and the Longitudinal Study of Aging Danish…
07-30-2019
‘Tickling’ the ear with a small electrical current appears to rebalance the autonomic nervous system for over-55s, potentially slowing down one of the effects of ageing, according to new research. Scientists found that a short daily therapy delivered for two weeks led to both physiological and wellbeing improvements,…
06-04-2019
Cessation, or even retardation of the ageing process is an appealing notion that has captured the imagination of humans for millennia. Even if it were possible to rejuvenate our bodies or retard the ageing process, how do we measure this? Age, as we know it, is clearly an inappropriate measurement because it is based…
06-01-2018
The Grim Reaper arrives for each of us eventually—wouldn’t it be nice to know when? Now UCLA researchers have developed a new tool to help you plan ahead for your date with the Angel of Death. Named after the grim reaper, the biomarker known as DNA methylation GrimAge, allows one to predict lifespan and healthspan,…
06-01-2018
The specific molecular mechanism of selective release and retention of senescence-associated sEV-mi RNAs and the EV-SASP cross talk between different cell types and its consequences in the context of aging and age-associated diseases, however, remains to be elucidated. Dr. Johannes Grillari said " We confirm that EVs…
06-01-2018
The researchers found a small core set of genes involved in stemness, proliferation and migration that showed consistent changes with advanced age in cells of renin lineage (CoRL)within the kidney. Surprisingly, most gene expression changes in CoRL aging are sex-specific: aged female mice showed up-regulation of…
06-01-2018
TPP-related compounds may provide a novel chemical strategy for effectively targeting bulk cancer cells and CSCs, while minimizing off-target side-effects in normal cells. Several independent lines of evidence support the idea that increased mitochondrial biogenesis or higher levels of mitochondrial protein…