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Online ISSN: 1945-4589
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06-01-2021
Aging published " Cdkn1a transcript variant 2 is a marker of aging and cellular senescence " which reported that cellular senescence is a cell fate response characterized by a permanent cell cycle arrest driven primarily the by cell cycle inhibitor and tumor suppressor proteins p16Ink4a and p21Cip1/Waf1. In mice, the…
05-27-2021
A groundbreaking clinical trial shows we can reduce biological age ( as measured by the Horvath 2013 DNAmAge clock ) by more than three years in only eight weeks with diet and lifestyle through balancing DNA methylation. A first-of-its-kind, peer-reviewed study provides scientific evidence that lifestyle and diet…
05-27-2021
Aging published " Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial " which reported on a randomized controlled clinical trial conducted among 43 healthy adult males between the ages of 50-72. The 8-week treatment program included diet, sleep, exercise and…
05-24-2021
Aging recently published " Intravitreal injection of anti-miRs against miR-142-3p reduces angiogenesis and microglia activation in a mouse model of laser- induced choroidal neovascularization " which reported that MiR-142-3p was overexpressed in murine CNV lesions and its pharmacological inhibition decreased vascular…
03-15-2021
Aging-US published " Functional analysis of POLD1 p.ser605del variant: the aging phenotype of MDPL syndrome is associated with an impaired DNA repair capacity " which reported that Mandibular hypoplasia, Deafness and Progeroid features with concomitant Lipodystrophy define a rare systemic disorder, named MDPL…
03-15-2021
Aging-US published " Impact of adiposity on muscle function and clinical events among elders with dynapenia, presarcopenia and sarcopenia: a community-based cross-sectional study " which reported that low muscle function determined unfavorable clinical outcome than low muscle mass; nevertheless, comparison of…
03-15-2021
Aging-US published " Aging and rejuvenation - a modular epigenome model " which reported that the view of aging has evolved in parallel with the advances in biomedical sciences. Long considered as an irreversible process where interventions were only aimed at slowing down its progression, breakthrough discoveries like…
02-17-2021
Aging-US published " In search of preventive strategies: novel high-CBD Cannabis sativa extracts modulate ACE2 expression in COVID-19 gateway tissues " which reported that Cannabis sativa , especially those high in the anti-inflammatory cannabinoid cannabidiol, has been found to alter gene expression and inflammation…
02-17-2021
Here is a link to a free Altmetric Report on this Research Output Aging-US published " Hyperbaric oxygen therapy increases telomere length and decreases immunosenescence in isolated blood cells: a prospective trial " which reported that the aim of the current study was to evaluate whether hyperbaric oxygen therapy…
02-17-2021
Here is a link to a video interview with Dr. David A. Sinclair about their research on the Aging-US YouTube Channel Here is a link to a free Altmetric Report on this Research Output Aging-US published " Why does COVID-19 disproportionately affect older people? " which reported that the severity and outcome of…
02-17-2021
Aging-US published " DNA- and telomere-damage does not limit lifespan: evidence from rapamycin " which reported that failure of rapamycin to extend lifespan in DNA repair mutant and telomerase-knockout mice, while extending lifespan in normal mice, indicates that neither DNA damage nor telomere shortening limits…
02-02-2021
Aging-US published " Anserine, HClO-scavenger, protected against cognitive decline in individuals with mild cognitive impairment " which reported that In this study, the authors aimed to evaluate the effects of anserine, a scavenger of HClO, on the protection of cognitive declines in persons with MCI. Fifty-eight…
02-02-2021
Aging-US published " A pro-diabetogenic mtDNA polymorphism in the mitochondrial-derived peptide, MOTS-c " which reported that although ethnic specific mtDNA polymorphisms have been shown to contribute to T2D risk, the functional effects of the mtDNA polymorphisms and the therapeutic potential of mitochondrial-derived…
02-02-2021
Aging-US published " Sulforaphane promotes C. elegans longevity and healthspan via DAF- 16/DAF-2 insulin/IGF-1 signaling " which reported that the broccoli-derived isothiocyanate sulforaphane inhibits inflammation, oxidative stress and cancer , but its effect on healthspan and longevity are unclear. The authors used…
02-02-2021
Aging-US published " Screening of Alzheimer’s disease by facial complexion using artificial intelligence " which reported that despite the increasing incidence and high morbidity associated with dementia, a simple, non-invasive, and inexpensive method of screening for dementia is yet to be discovered. This study aimed…
01-19-2021
Aging-US Issue 1 Volume 13 features " PAM (PIK3/AKT/mTOR) signaling in glia: potential contributions to brain tumors in aging " which reported that despite a growing proportion of aged individuals at risk for developing cancer in the brain, the prognosis for these conditions remains abnormally poor due to limited…
01-19-2021
Aging-US published " Neuroprotective effects and mechanisms of action of nicotinamide mononucleotide (NMN) in a photoreceptor degenerative model of retinal detachment " which reported that here, the authors investigated nicotinamide mononucleotide , a precursor of nicotinamide adenine dinucleotide , in a retinal…
12-15-2020
Aging-US recently published " Transforming growth factor beta type 1 (TGF-β) and hypoxia-inducible factor 1 (HIF-1) transcription complex as master regulators of the immunosuppressive protein galectin-9 expression in human cancer and embryonic cells " which reported that for the first time that in human cancer as well…
11-16-2020
Aging-US recently published " Identification of genomic alterations and associated transcriptomic profiling reveal the prognostic significance of MMP14 and PKM2 in patients with pancreatic cancer " which reported that Integrated analysis of The Cancer Genome Atlas datasets revealed that KRAS mutation, TP53 mutation…
11-13-2020
Aging-US recently published " Knockdown of TXNDC9 induces apoptosis and autophagy in glioma and mediates cell differentiation by p53 activation " which reported that no research associated with TXNDC9 has been reported in glioma. In this study, the found that TXNDC9 was upregulated in glioma. Knockdown of TXNDC9 would…