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11-13-2020
Aging-US recently published " Alzheimer’s disease as a systems network disorder: chronic stress/dyshomeostasis, innate immunity, and genetics " which reported that ineffective results of clinical trials of over 200 anti-Alzheimer's drug candidates, with a 99.6% attrition rate, suggest that the current paradigm of…
11-10-2020
Aging-US recently published " MiR-520d-5p modulates chondrogenesis and chondrocyte metabolism through targeting HDAC1 " which reported that this study aimed to determine miRNAs associated with chondrogenesis of human mesenchymal stem cells and chondrocyte metabolism. MiRNAs were screened in hMSCs during chondrogenesis…
11-10-2020
Aging-US recently published " Lipopolysaccharide upregulates miR-132/212 in Hirschsprung-associated enterocolitis, facilitating pyroptosis by activating NLRP3 inflammasome via targeting Sirtuin 1 (SIRT1) " which reported that MiR-132 and miR-212 were up-regulated in HAEC dilated tissues and LPS-treated mice enteritis…
11-10-2020
Aging-US recently published " GPA peptide inhibits NLRP3 inflammasome activation to ameliorate colitis through AMPK pathway " which reported that pyroptosis and NLRP3 inflammasome are associated with various kinds of inflammatory diseases including colitis. In vivo, the authors found GPA peptide could exert…
11-10-2020
Aging-US recently published " Characterization of LncRNA SNHG22 as a protector of NKIRAS2 through miR-4492 binding in osteosarcoma \” which reported that the underlying mechanism of SNHG22 in regulating OS progression remains unknown. In this study, the authors confirmed that SNHG22 was downregulated in OS, and the…
11-10-2020
Aging-US recently published " Psychological aging, depression, and well-being " which reported that Aging is a multifactorial process, which affects the human body on every level and results in both biological and psychological changes. These factors can be used for a future development of individual psychological…
10-05-2020
Aging-US recently published " From Causes of Aging to Death from COVID-19 " by Blagosklonny et al. which reported that COVID-19 is not deadly early in life, but mortality increases exponentially with age - which is the strongest predictor of mortality. The Review covers: Age Age-related diseases Male Gender Mortality…
06-29-2020
The cover for issue 12 of Aging-US features " SIRT6 mono-ADP ribosylates KDM2A to locally increase H3K36me2 at DNA damage sites to inhibit transcription and promote repair " by Rezazadeh et al. and reported that when transcribed DNA is damaged, the transcription and DNA repair machinery must interact to ensure…
04-20-2020
Volume 12, Issue 8 of @AgingJrnl reported that similarly, two proposed therapeutics for the treatment of COVID-19 infection are Azithromycin and Quercetin, both drugs with significant senolytic activity. Therefore, the authors wish to speculate that the fight against COVID-19 disease should involve testing the…
04-03-2020
Friday, 3rd of April, 2020, London, UK - The Biogerontology Research Foundation, a registered UK charity supporting and promoting aging and longevity research worldwide since 2008, today announced the publication of a paper titled “ Geroprotective and senoremediative strategies to reduce the comorbidity, infection…
02-13-2020
Aging-US Volume 12, Issue 2 reported that Younger females are protected from adipose inflammation, but older post-menopausal females exhibit exaggerated visceral adiposity correlated with increased disease risk. Obesity accelerates the onset and progression of age-associated diseases, but it is unclear if aging and…
02-13-2020
The cover features Figure 9 "Resveratrol enhances antitumor T cell immunity by promoting abnormal glycosylation and dimerization of PD-L1." from Verdura et al. . RSV was also predicted to interact with the inner surface of PD-L1 involved in the interaction with PD-1, almost perfectly occupying the target space of the…
02-13-2020
The cover features Figure 7 "Scheme of epigenetic and molecular mechanisms changed in 5XFAD mice induced by pharmacological inhibition of G9a/GLP by UNC0642" from Griñán-Ferré et al . UNC0642, a specific and potent inhibitor of methyltransferase activity G9a/GLP complex, was evaluated in the 5XFAD mouse model. UNC0642…
12-03-2019
Deep biomarkers of aging and longevity: from research to applications The deep age predictors can help advance aging research by establishing causal relationships in nonlinear systems . Deep aging clocks can be used for identification of novel therapeutic targets, evaluating the efficacy of various interventions, data…
11-18-2019
The cover features Figure 3 "Calculated bioenergetic health index (BHI) from young and old CD4+ T cells" from Bektas et al. Though mitochondrial number in both naive and memory cells visualized with electron microcopy was similar in older versus younger participants, there were a significantly higher number of…
11-05-2019
The cover features Figure 4 "SAMP8 mice display a spontaneous OA phenotype" from Malaise The research team tests whether by becoming senescent, the mesenchymal stromal/stem cells, found in the synovial tissue and sub-chondral bone marrow, can contribute to OA development. When co-cultured with OA chondrocytes,…
10-14-2019
The scientist discusses several reasons, including fear of the actual and fictional side effects of rapamycin, everolimus and other clinically-approved drugs, arguing that no real side effects preclude their use as anti-aging drugs today. They go on to discuss why it is more dangerous not to use anti-aging drugs than…
10-06-2019
The researchers examined the contribution of N-methyl-D-aspartate receptor subunits in the redox-mediated decline in NMDAR function during aging. Glu N2A and Glu N2B selective antagonists decreased peak NMDAR currents to a similar extent in young and aged animals, indicating that a shift in diheteromeric Glu N2…
10-05-2019
Due to strain-specific behavioral idiosyncrasies, inbred mouse strains are suboptimal research models for behavioral aging studies. The researchers found that both males and females demonstrated decreased exploratory behavior with age, while memory and depressive-like behavior were maintained. Dr. Malin Hernebring…
10-04-2019
The researchers recruited healthy older participants to two groups according to their history of tea drinking frequency and investigated both functional and structural networks to reveal the role of tea drinking on brain organization. The suppression of hemispheric asymmetry in the structural connectivity network was…