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• Editorial

  Targeted cancer therapy: the initial high concentration may slow down the selection for resistance

  Relevance score: 10.916708

  Mikhail V. Blagosklonny

  Keywords: lung cancer, resistance, brain metastases, METex14, capmatinib, rapamycin

  Published in Aging on July 28, 2024

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  Unfortunately, any targeted therapy is, always, started with low levels of the drug in the organism, selecting for drug resistance. One should propose that initial drug levels must be maximized and durations may be minimized, ideally, as portions of preemptive combination of targeted drugs.