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• Research PaperVolume 11, Issue 15pp 5817-5828

  The senescence-associated secretory phenotype (SASP) from mesenchymal stromal cells impairs growth of immortalized prostate cells but has no effect on metastatic prostatic cancer cells

  Relevance score: 0.00

  Nicola Alessio, Domenico Aprile, Tiziana Squillaro, Giovanni Di Bernardo, Mauro Finicelli, Mariarosa AB Melone, Gianfranco Peluso, Umberto Galderisi

  Keywords: mesenchymal stem cells, senescence, secretome

  Published in Aging on August 14, 2019

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• Research PaperVolume 16, Issue 4pp 3350-3362

  Single-cell transcriptomics identifies senescence-associated secretory phenotype (SASP) features of testicular aging in human

  Relevance score: 0.00

  Junxian He, Jindong Li, Yanqing Li, Zhenhan Xu, Menghui Ma, Haicheng Chen, Peigen Chen, Linyan Lv, Xuejun Shang, Guihua Liu

  Keywords: single-cell transcriptome, senescence-associated secretory phenotype (SASP), aging testis, spermatogenesis microenvironment

  Published in Aging on February 12, 2024

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• Research PaperVolume 8, Issue 7pp 1316-1327

  Unbiased analysis of senescence associated secretory phenotype (SASP) to identify common components following different genotoxic stresses

  Relevance score: 0.00

  Servet Özcan, Nicola Alessio, Mustafa B. B. Acar, Eda Mert, Fatih Omerli, Gianfranco Peluso, Umberto Galderisi

  Keywords: mesenchymal stem cells, senescence, secretome

  Published in Aging on June 9, 2016

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• Research PaperVolume 17, Issue 3pp 757-777

  Inhibition of the metalloprotease ADAM19 as a novel senomorphic strategy to ameliorate gut permeability and senescence markers by modulating senescence-associated secretory phenotype (SASP)

  Relevance score: 0.00

  Sudipta Bar, Tyler A.U. Hilsabeck, Blaine Pattavina, José Alberto López-Domínguez, Nathan Basisty, Joanna Bons, Mark Watson, Birgit Schilling, Judith Campisi, Pankaj Kapahi, Amit Sharma

  Keywords: aging, senescence, drosophila, SASP

  Published in Aging on March 20, 2025

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• Research PaperVolume 10, Issue 5pp 1103-1132

  Small extracellular vesicles and their miRNA cargo are anti-apoptotic members of the senescence-associated secretory phenotype

  Relevance score: 0.00

  Lucia Terlecki-Zaniewicz, Ingo Lämmermann, Julie Latreille, Madhusudhan Reddy Bobbili, Vera Pils, Markus Schosserer, Regina Weinmüllner, Hanna Dellago, Susanna Skalicky, Dietmar Pum, Juan Carlos Higareda Almaraz, Marcel Scheideler, Frédérique Morizot, Matthias Hackl, Florian Gruber, Johannes Grillari

  Keywords: senescence-associated secretory phenotype (SASP), cellular senescence, small extracellular vesicle (sEV), exosomes, microRNA (miRNA)

  Published in Aging on May 19, 2018

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• Research PaperVolume 11, Issue 2pp 549-572

  S100A13 promotes senescence-associated secretory phenotype and cellular senescence via modulation of non-classical secretion of IL-1α

  Relevance score: 0.00

  Yuanyuan Su, Chenzhong Xu, Zhaomeng Sun, Yao Liang, Guodong Li, Tanjun Tong, Jun Chen

  Keywords: S100A13, non-classical protein secretory pathway, IL-1α, SASP, Cu ²⁺, cell senescence

  Published in Aging on January 23, 2019

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• Research PaperVolume 16, Issue 9pp 8070-8085

  KLF4 inhibited the senescence-associated secretory phenotype in ox-LDL-treated endothelial cells via PDGFRA/NAMPT/mitochondrial ROS

  Relevance score: 0.00

  Haoran Ding, Jing Tong, Hao Lin, Fan Ping, Tongqing Yao, Zi Ye, Jiapeng Chu, Deqiang Yuan, Kangwei Wang, Xuebo Liu, Fei Chen

  Keywords: endothelial cells, SASP, KLF4, PDGFRA, NAMPT/mitochondrial ROS

  Published in Aging on May 8, 2024

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• Research PaperVolume 14, Issue 20pp 8167-8178

  Downregulation of senescence-associated secretory phenotype by knockdown of secreted frizzled-related protein 4 contributes to the prevention of skin aging

  Relevance score: 0.00

  Kento Takaya, Toru Asou, Kazuo Kishi

  Keywords: skin, fibroblast, SASP, SFRP4

  Published in Aging on September 7, 2022

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• Research PaperVolume 11, Issue 12pp 4145-4158

  Intestinal stem cells acquire premature senescence and senescence associated secretory phenotype concurrent with persistent DNA damage after heavy ion radiation in mice

  Relevance score: 0.00

  Santosh Kumar, Shubhankar Suman, Albert J Fornace, Kamal Datta

  Keywords: heavy ion radiation, space radiation, radiotherapy, intestinal stem cell, senescence, premature aging, SASP

  Published in Aging on June 25, 2019

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• Research PaperVolume 8, Issue 3pp 484-505

  MicroRNA-15b regulates mitochondrial ROS production and the senescence-associated secretory phenotype through sirtuin 4/SIRT4

  Relevance score: 0.00

  Alexander Lang, Susanne Grether-Beck, Madhurendra Singh, Fabian Kuck, Sascha Jakob, Andreas Kefalas, Simone Altinoluk-Hambüchen, Nina Graffmann, Maren Schneider, Antje Lindecke, Heidi Brenden, Ingo Felsner, Hakima Ezzahoini, Alessandra Marini, Sandra Weinhold, Andrea Vierkötter, Julia Tigges, Stephan Schmidt, Kai Stühler, Karl Köhrer, Markus Uhrberg, Judith Haendeler, Jean Krutmann, Roland P. Piekorz

  Keywords: MicroRNA-15b/miR-15b, nuclear encoded mitochondrial genes, photoaging, reactive oxygen species/ROS, senescence, senescence associated secretory phenotype/SASP, SIRT4/Sirtuin 4, skin

  Published in Aging on February 26, 2016

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• Research PaperVolume 16, Issue 18pp 12651-12666

  Unveiling senescence-associated secretory phenotype in epidermal aging: insights from reversibly immortalized keratinocytes

  Relevance score: 0.00

  Lu-Wen Xu, Yi-Dan Sun, Qiao-Yu Fu, Dan Wu, Jian Lin, Chen Wang, Liang Zhang, Cai-Yue Liu, Qing-Feng Li

  Keywords: keratinocytes, epidermis, aging, immortalized cells, SV40T

  Published in Aging on September 23, 2024

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• Research PaperVolume 4, Issue 10pp 695-708

  NF90 coordinately represses the senescence-associated secretory phenotype

  Relevance score: 0.00

  Kumiko Tominaga-Yamanaka, Kotb Abdelmohsen, Jennifer L. Martindale, Xiaoling Yang, Dennis D. Taub, Myriam Gorospe

  Keywords: RNA-binding protein, ribonucleoprotein complex, mRNA translation, mRNA stability, post-transcriptional gene regulation, senescence

  Published in Aging on October 31, 2012

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• Research PaperVolume 13, Issue 3pp 3290-3312

  Suppression of p16 alleviates the senescence-associated secretory phenotype

  Relevance score: 0.00

  Raquel Buj, Kelly E. Leon, Marlyn A. Anguelov, Katherine M. Aird

  Keywords: interleukin-6, interleukin-8, LMNB1, inflammation, melanoma

  Published in Aging on February 6, 2021

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• Priority Research PaperVolume 13, Issue 18pp 21838-21854

  SARS-CoV-2 causes senescence in human cells and exacerbates the senescence-associated secretory phenotype through TLR-3

  Relevance score: 0.00

  Utkarsh Tripathi, Rayhane Nchioua, Larissa G. P. Langhi Prata, Yi Zhu, Erin O. Wissler Gerdes, Nino Giorgadze, Tamar Pirtskhalava, Erik Parker, Ailing Xue, Jair Machado Espindola-Netto, Steffen Stenger, Paul D. Robbins, Laura J. Niedernhofer, Stephanie L. Dickinson, David B. Allison, Frank Kirchhoff, Konstantin Maria Johannes Sparrer, Tamar Tchkonia, James L. Kirkland

  Keywords: SARS-COV-2, senescence, toll like receptor 3, COVID-19

  Published in Aging on September 16, 2021

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• Research PaperVolume 15, Issue 9pp 3331-3355

  In vitro and in vivo effects of zoledronic acid on senescence and senescence-associated secretory phenotype markers

  Relevance score: 0.00

  Parinya Samakkarnthai, Dominik Saul, Lei Zhang, Zaira Aversa, Madison L. Doolittle, Jad G. Sfeir, Japneet Kaur, Elizabeth J. Atkinson, James R. Edwards, Graham G. Russell, Robert J. Pignolo, James L. Kirkland, Tamar Tchkonia, Laura J. Niedernhofer, David G. Monroe, Nathan K. Lebrasseur, Joshua N. Farr, Paul D. Robbins, Sundeep Khosla

  Keywords: senescence, senolytics, aging, bone, bisphosphonates

  Published in Aging on May 7, 2023

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• Research PaperVolume 8, Issue 8pp 1608-1624

  A miR-335/COX-2/PTEN axis regulates the secretory phenotype of senescent cancer-associated fibroblasts

  Relevance score: 0.00

  Tasnuva D. D. Kabir, Ross J. J. Leigh, Hataitip Tasena, Massimiliano Mellone, Ricardo D. D. Coletta, Eric K. K. Parkinson, Stephen S. S. Prime, Gareth J. J. Thomas, Ian C. C. Paterson, Donghui Zhou, John McCall, Paul M. M. Speight, Daniel W. W. Lambert

  Keywords: miR-335, PTEN, fibroblast, CAF, SASP, COX-2

  Published in Aging on June 29, 2016

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• Research PaperVolume 12, Issue 24pp 24853-24871

  Aberrant RhoA activation in macrophages increases senescence-associated secretory phenotypes and ectopic calcification in muscular dystrophic mice

  Relevance score: 0.00

  Xiaodong Mu, Chi-Yi Lin, William S. Hambright, Ying Tang, Sudheer Ravuri, Aiping Lu, Polina Matre, Wanqun Chen, Xueqin Gao, Yan Cui, Ling Zhong, Bing Wang, Johnny Huard

  Keywords: heterotopic ossification, cellular senescence, muscle dystrophy, muscle stem cell, chronic inflammation

  Published in Aging on December 23, 2020

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• Research PaperVolume 16, Issue 4pp 3068-3087

  Mapping the core senescence phenotype of primary human colon fibroblasts

  Relevance score: 0.00

  Namita Ganesh Hattangady, Kelly Carter, Brett Maroni-Rana, Ting Wang, Jessica Lee Ayers, Ming Yu, William M. Grady

  Keywords: senescence, senescence associated secretory phenotype, SASP, colorectal cancer, cancer

  Published in Aging on February 21, 2024

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• Research PaperVolume 5, Issue 12pp 913-924

  Age-associated stresses induce an anti-inflammatory senescent phenotype in endothelial cells

  Relevance score: 0.00

  Paul R. Coleman, Garry Chang, Gabor Hutas, Matthew Grimshaw, Mathew A. Vadas, Jennifer R. Gamble

  Keywords: senescence, endothelial cells, inflammation, ARHGAP18, SENEX, ageing

  Published in Aging on December 12, 2013

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• Priority Research PaperVolume 13, Issue 15pp 19088-19107

  Senescence-associated hyper-activation to inflammatory stimuli in vitro

  Relevance score: 0.00

  Vivekananda Budamagunta, Sahana Manohar-Sindhu, Yang Yang, Yonghan He, Dmitry O. Traktuev, Thomas C. Foster, Daohong Zhou

  Keywords: cellular senescence, inflammation, SASP

  Published in Aging on August 10, 2021

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