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Page: 12 of 2

• Research PaperVolume 18, Issue 1pp 833-853

  Slowing intervertebral disc aging in mice through long-term systemic treatment with the senolytic BCL-2/BCL-xL proteolysis targeting chimera (PROTAC) 753b

  Relevance score: 0.00

  Peter G. Alexander, Bowen Yan, Karen L. Clark, Qing Dong, Dong Wang, Yang Yang, Ting Zhang, Peiyi Zhang, Guangrong Zheng, Paul D. Robbins, Gwendolyn A. Sowa, Joon Y. Lee, Daohong Zhou, Nam Viet Vo

  Keywords: intervertebral disc aging, cellular senescence, senolytic, anti-apoptosis, PROTAC-753b

  Published in Aging on July 13, 2026

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• Research PaperVolume 12, Issue 12pp 12285-12304

  Influences of circulatory factors on intervertebral disc aging phenotype

  Relevance score: 0.00

  Changbin Lei, Debora Colangelo, Prashanti Patil, Vivian Li, Kevin Ngo, Dong Wang, Qing Dong, Matthew J. Yousefzadeh, Hongsheng Lin, Joon Lee, James Kang, Gwendolyn Sowa, Tony Wyss-Coray, Laura J. Niedernhofer, Paul D. Robbins, Derek M. Huffman, Nam Vo

  Keywords: intervertebral disc, heterochronic parabiosis, systemic factors, proteoglycan, aging

  Published in Aging on June 11, 2020

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• Research PaperVolume 17, Issue 9pp 2369-2391

  Runx1 overexpression induces early onset of intervertebral disc degeneration

  Relevance score: 0.00

  Takanori Fukunaga, Martha Elena Diaz-Hernandez, John G. Heller, Changli Zhang, Hicham Drissi

  Keywords: cell senescence, aging, Runx1, nucleus pulposus, intervertebral disc degeneration

  Published in Aging on September 8, 2025

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• Research PaperVolume 14, Issue 5pp 2400-2417

  Manual therapy regulates oxidative stress in aging rat lumbar intervertebral discs through the SIRT1/FOXO1 pathway

  Relevance score: 0.00

  Chongjie Yao, Guangxin Guo, Ruixin Huang, Cheng Tang, Qingguang Zhu, Yanbin Cheng, Lingjun Kong, Jun Ren, Min Fang

  Keywords: manual therapy, aging, intervertebral disc degeneration, oxidative stress, SIRT1/FOXO1 pathway

  Published in Aging on March 15, 2022

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• Research PaperVolume 16, Issue 12pp 10216-10238

  Oxidative stress-induced EGR1 upregulation promotes NR4A3-mediated nucleus pulposus cells apoptosis in intervertebral disc degeneration

  Relevance score: 0.00

  Si-Kuan Zheng, Xiao-Kun Zhao, Hui Wu, Ding-Wen He, Long Xiong, Xi-Gao Cheng

  Keywords: intervertebral disc degeneration, EGR1, NR4A3, nucleus pulposus, apoptosis

  Published in Aging on June 28, 2024

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• RetractionVolume 16, Issue 10pp 9305-9305

  Retraction for: DNMT3B decreases extracellular matrix degradation and alleviates intervertebral disc degeneration through TRPA1 methylation to inhibit the COX2/YAP axis

  Relevance score: 0.00

  Zhiqiang Luo, Yanchao Ma, Tianning Di, Bing Ma, Hongwei Li, Jiangdong An, Yonggang Wang, Haihong Zhang

  Keywords: intervertebral disc degeneration, nucleus pulposus, extracellular matrix, inflammation, DNA methyltransferase

  Published in Aging on May 31, 2024

• Research PaperVolume 16, Issue 6pp 5050-5064

  Omilancor mitigates the senescence of nucleus pulposus cells induced by DDP through targeting MAP2K6

  Relevance score: 0.00

  Fang Yafeng, Shi Xinpeng, Wei Rong, Cui Guofeng

  Keywords: intervertebral disc degeneration, Omilancor, cellular senescence, MAP2K6

  Published in Aging on March 20, 2024

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• Research PaperVolume 16, Issue 6pp 5370-5386

  Comprehensive analysis of gene expression profiles of annulus fibrosus subtypes and hub genes in intervertebral disc degeneration

  Relevance score: 0.00

  Xiaokun Zhao, Jian Zhang, Jiahao Liu, Jinghong Yuan, Tianlong Wu, Xigao Cheng

  Keywords: intervertebral disc degeneration, annulus fibrosus, molecular subtype, WGCNA, machine learning

  Published in Aging on March 13, 2024

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• Research PaperVolume 15, Issue 24pp 15599-15623

  Unravelling diagnostic clusters and immune landscapes of cuproptosis patterns in intervertebral disc degeneration through dry and wet experiments

  Relevance score: 0.00

  Peng Zhang, Jiahui He, Yanchi Gan, Qi Shang, Honglin Chen, Wenhua Zhao, Jianchao Cui, Gengyang Shen, Yuwei Li, Xiaobing Jiang, Guangye Zhu, Hui Ren

  Keywords: intervertebral disc degeneration, cuproptosis biomarkers, subtype classification, immune microenvironment infiltration, experimental validation

  Published in Aging on December 29, 2023

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• Research PaperVolume 15, Issue 24pp 14764-14790

  Conjoint research of WGCNA, single-cell transcriptome and structural biology reveals the potential targets of IDD development and treatment and JAK3 involvement

  Relevance score: 0.00

  Yingjing Zhao, Yuxue Mu, Yujia Zou, Zhijian He, Tianxing Lu, Xinhui Wang, Weihang Li, Bo Gao

  Keywords: intervertebral disc degeneration, weighted gene co-expression network analysis, Janus kinase family, high-throughput virtual screening, single-cell transcriptome

  Published in Aging on December 12, 2023

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• Research PaperVolume 15, Issue 23pp 13693-13709

  The antioxidant Glycitin protects against intervertebral disc degeneration through antagonizing inflammation and oxidative stress in nucleus pulposus cells

  Relevance score: 0.00

  Wei Zhao, Yanpei Li, Xiang Cheng, Hui Wei, Peng Li, Lixia Fan, Kaiwen Liu, Shuai Zhang, Hao Wang

  Keywords: intervertebral disc degeneration, Glycitin, inflammation, TNF-α, ROS

  Published in Aging on November 28, 2023

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• Research PaperVolume 15, Issue 10pp 4288-4303

  DNMT1 regulates polarization of macrophage-induced intervertebral disc degeneration by modulating SIRT6 expression and promoting pyroptosis in vivo

  Relevance score: 0.00

  Yang Hou, Jiangang Shi, Yongfei Guo, Guodong Shi

  Keywords: intervertebral disc degeneration, macrophage polarization, DNA methyltransferase 1, sirtuin 6

  Published in Aging on May 17, 2023

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• Research PaperVolume 13, Issue 18pp 22459-22473

  miR-19b-3p relieves intervertebral disc degeneration through modulating PTEN/PI3K/Akt/mTOR signaling pathway

  Relevance score: 0.00

  Yulin Zhao, Aimin Li

  Keywords: intervertebral disc degeneration, miR-19b-3p, PTEN, apoptosis, signaling pathways

  Published in Aging on September 23, 2021

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• Research PaperVolume 13, Issue 16pp 20258-20276

  DNMT3B decreases extracellular matrix degradation and alleviates intervertebral disc degeneration through TRPA1 methylation to inhibit the COX2/YAP axis

  Relevance score: 0.00

  Zhiqiang Luo, Yanchao Ma, Tianning Di, Bing Ma, Hongwei Li, Jiangdong An, Yonggang Wang, Haihong Zhang

  Keywords: intervertebral disc degeneration, nucleus pulposus, extracellular matrix, inflammation, DNA methyltransferase

  Published in Aging on August 24, 2021

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• Research PaperVolume 13, Issue 10pp 14185-14197

  Circular RNA ITCH promotes extracellular matrix degradation via activating Wnt/β-catenin signaling in intervertebral disc degeneration

  Relevance score: 0.00

  Feng Zhang, Feili Lin, Zhiwen Xu, Zheng Huang

  Keywords: intervertebral disc degeneration, extracellular matrix ECM degradation, circITCH, miR-17-5p, SOX4

  Published in Aging on May 18, 2021

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• Research PaperVolume 13, Issue 7pp 10703-10723

  ASIC1 and ASIC3 mediate cellular senescence of human nucleus pulposus mesenchymal stem cells during intervertebral disc degeneration

  Relevance score: 0.00

  Jingyu Ding, Renjie Zhang, Huimin Li, Qiang Ji, Xiaomin Cheng, Rick Francis Thorne, Hubert Hondermarck, Xiaoying Liu, Cailiang Shen

  Keywords: intervertebral disc degeneration (IVDD), nucleus pulposus mesenchymal stem cells (NP-MSCs), acid sensing ion channels (ASICs), cellular senescence

  Published in Aging on April 6, 2021

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• Research PaperVolume 12, Issue 8pp 7534-7548

  Protective effects of autophagy and NFE2L2 on reactive oxygen species-induced pyroptosis of human nucleus pulposus cells

  Relevance score: 0.00

  Zhibiao Bai, Wei Liu, Danshuang He, Yiyang Wang, Weiwei Yi, Changqi Luo, Jieliang Shen, Zhenming Hu

  Keywords: intervertebral disc degeneration, nucleus pulposus cells, pyroptosis, transcription factor, autophagy

  Published in Aging on April 22, 2020

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• Research PaperVolume 11, Issue 23pp 10814-10825

  Long noncoding RNA LINC00958 accelerates the proliferation and matrix degradation of the nucleus pulposus by regulating miR-203/SMAD3

  Relevance score: 0.00

  Kunchi Zhao, Yang Zhang, Hongping Yuan, Mingming Zhao, Dongxu Zhao

  Keywords: intervertebral disc degeneration, LINC00958, miR-203, nucleus pulposus

  Published in Aging on December 5, 2019

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• Research PaperVolume 11, Issue 22pp 10499-10512

  Melatonin modulates IL-1β-induced extracellular matrix remodeling in human nucleus pulposus cells and attenuates rat intervertebral disc degeneration and inflammation

  Relevance score: 0.00

  Yan Zhang, Fan He, Zhi Chen, Qihang Su, Meijun Yan, Qiang Zhang, Jun Tan, Lie Qian, Yingchao Han

  Keywords: intervertebral disc degeneration, nucleus pulposus cells, melatonin, inflammation

  Published in Aging on November 26, 2019

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• Research PaperVolume 11, Issue 22pp 10252-10265

  Metformin decreases LPS-induced inflammatory response in rabbit annulus fibrosus stem/progenitor cells by blocking HMGB1 release

  Relevance score: 0.00

  Yingchao Han, Feng Yuan, Chao Deng, Fan He, Yan Zhang, Hongxing Shen, Zhi Chen, Lie Qian

  Keywords: intervertebral disc degeneration, annulus fibrosis stem cells, cell senescence, HMGB1, metformin

  Published in Aging on November 26, 2019

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