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• EditorialVolume 8, Issue 11pp 2609-2610

  Biocomputing drug repurposing toward targeted therapies

  Relevance score: 0.00

  Luca Cardone

  Keywords: oncogenes, PI3K-dependent pathways, gene expression signatures, drugs network, FDA-approved drugs

  Published in Aging on November 30, 2016

• Research PaperVolume 15, Issue 11pp 5144-5163

  Network medicine framework identified drug-repurposing opportunities of pharmaco-active compounds of Angelica acutiloba (Siebold & Zucc.) Kitag. for skin aging

  Relevance score: 0.00

  Jiaxin Mo, Zunjiang Li, Hankun Chen, Zhongyu Lu, Banghan Ding, Xiaohong Yuan, Yuan Liu, Wei Zhu

  Keywords: network medicine framework, drug-repurposing opportunities, Angelica acutiloba (Siebold & Zucc.) Kitag., skin aging, pharmaco-active compounds

  Published in Aging on June 12, 2023

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• Research PaperVolume 12, Issue 19pp 19022-19044

  Target RNA modification for epigenetic drug repositioning in neuroblastoma: computational omics proximity between repurposing drug and disease

  Relevance score: 0.00

  Pei Ma, Lifeng Yue, Sen Zhang, Dacheng Hao, Zhihong Wu, Lijia Xu, Guanhua Du, Peigen Xiao

  Keywords: neuroblastoma, drug repurposing, gene expression, the connectivity map, L1000 FWD

  Published in Aging on October 12, 2020

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• Research PaperVolume 10, Issue 11pp 3294-3307

  Azithromycin and Roxithromycin define a new family of “senolytic” drugs that target senescent human fibroblasts

  Relevance score: 0.00

  Bela Ozsvari, John R. Nuttall, Federica Sotgia, Michael P. Lisanti

  Keywords: drug repurposing, aging, senescence, senolytic drugs, antibiotics, azithromycin, roxithromycin

  Published in Aging on November 14, 2018

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• Research PaperVolume 8, Issue 9pp 2127-2152

  In search for geroprotectors: in silico screening and in vitro validation of signalome-level mimetics of young healthy state

  Relevance score: 0.00

  Alexander Aliper, Aleksey V. Belikov, Andrew Garazha, Leslie Jellen, Artem Artemov, Maria Suntsova, Alena Ivanova, Larisa Venkova, Nicolas Borisov, Anton Buzdin, Polina Mamoshina, Evgeny Putin, Andrew G. Swick, Alexey Moskalev, Alex Zhavoronkov

  Keywords: geroprotector, drug discovery, screening, drug repurposing, aging

  Published in Aging on September 24, 2016

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• Research PaperVolume 17, Issue 11pp 2844-2858

  REVIVE: a computational platform for systematically identifying rejuvenating chemical and genetic perturbations

  Relevance score: 0.00

  Sascha Jung, Javier Arcos Hodar, Tejwasi Venkata S. Badam, Antonio del Sol

  Keywords: computational modeling, machine learning, aging, rejuvenation, drug repurposing

  Published in Aging on November 25, 2025

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• Research PaperVolume 13, Issue 13pp 17407-17427

  Antiparasitic mebendazole (MBZ) effectively overcomes cisplatin resistance in human ovarian cancer cells by inhibiting multiple cancer-associated signaling pathways

  Relevance score: 0.00

  Linjuan Huang, Ling Zhao, Jing Zhang, Fang He, Hao Wang, Qing Liu, Deyao Shi, Na Ni, William Wagstaff, Connie Chen, Russell R. Reid, Rex C. Haydon, Hue H. Luu, Le Shen, Tong-Chuan He, Liangdan Tang

  Keywords: ovarian cancer, cisplatin, chemoresistance, cisplatin resistance, mebendazole (MBZ), drug repurposing

  Published in Aging on July 7, 2021

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• Research PerspectiveVolume 12, Issue 8pp 6511-6517

  COVID-19 and chronological aging: senolytics and other anti-aging drugs for the treatment or prevention of corona virus infection?

  Relevance score: 0.00

  Camillo Sargiacomo, Federica Sotgia, Michael P. Lisanti

  Keywords: COVID-19, corona virus, aging, senescence, senolytic drug therapy, prevention, viral replication, drug repurposing, antibiotic, Azithromycin, Hydroxy-chloroquine, Rapamycin, Doxycycline, Quercetin

  Published in Aging on March 30, 2020

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• Research PaperVolume 8, Issue 8pp 1593-1606

  Bedaquiline, an FDA-approved antibiotic, inhibits mitochondrial function and potently blocks the proliferative expansion of stem-like cancer cells (CSCs)

  Relevance score: 0.00

  Marco Fiorillo, Rebecca Lamb, Herbert B. B. Tanowitz, Anna Rita Rita Cappello, Ubaldo E. E. Martinez-Outschoorn, Federica Sotgia, Michael P. P. Lisanti

  Keywords: bedaquiline, mitochondria, tumor-initiating cells (TICs), cancer stem-like cells (CSCs), drug repurposing

  Published in Aging on June 22, 2016

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• Research PaperVolume 12, Issue 16pp 16514-16538

  Coupled immune stratification and identification of therapeutic candidates in patients with lung adenocarcinoma

  Relevance score: 0.00

  Weilei Hu, Guosheng Wang, Yundi Chen, Lonny B. Yarmus, Biao Liu, Yuan Wan

  Keywords: personalized cancer immunotherapies, drug repositioning, cold tumor, patient stratification, tumor microenvironment

  Published in Aging on August 27, 2020

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• Research PaperVolume 14, Issue 6pp 2475-2506

  Hallmarks of aging-based dual-purpose disease and age-associated targets predicted using PandaOmics AI-powered discovery engine

  Relevance score: 0.00

  Frank W. Pun, Geoffrey Ho Duen Leung, Hoi Wing Leung, Bonnie Hei Man Liu, Xi Long, Ivan V. Ozerov, Ju Wang, Feng Ren, Alexander Aliper, Evgeny Izumchenko, Alexey Moskalev, João Pedro de Magalhães, Alex Zhavoronkov

  Keywords: artificial intelligence, deep learning, drug discovery, multi-omics, target identification

  Published in Aging on March 29, 2022

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• Research PaperVolume 16, Issue 7pp 6384-6416

  Using genetics and proteomics data to identify proteins causally related to COVID-19, healthspan and lifespan: a Mendelian randomization study

  Relevance score: 0.00

  Jie V. Zhao, Minhao Yao, Zhonghua Liu

  Keywords: proteomics, healthspan, lifespan, COVID-19

  Published in Aging on April 3, 2024

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• Research PaperVolume 11, Issue 14pp 4801-4835

  Mitochondrial and ribosomal biogenesis are new hallmarks of stemness, oncometabolism and biomass accumulation in cancer: Mito‐stemness and ribo‐stemness features

  Relevance score: 0.00

  Maria Peiris‐Pagès, Béla Ozsvári, Federica Sotgia, Michael P. Lisanti

  Keywords: coculture, tumor microenvironment, proteomics, mito-stemness, ribo-stemness, mitochondria, protein synthesis, organelle biogenesis

  Published in Aging on July 16, 2019

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• Research PaperVolume 11, Issue 17pp 6691-6713

  PU-91 drug rescues human age-related macular degeneration RPE cells; implications for AMD therapeutics

  Relevance score: 0.00

  Sonali Nashine, Sudhakar R. Subramaniam, Marilyn Chwa, Anthony Nesburn, Baruch D. Kuppermann, Howard Federoff, M. Cristina Kenney

  Keywords: age-related macular degeneration (AMD), RPE, PGC-1α, mitochondria, FDA-approved drugs

  Published in Aging on September 2, 2019

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• Research PaperVolume 16, Issue 1pp 627-647

  Targeting of FSP1 regulates iron homeostasis in drug-tolerant persister head and neck cancer cells via lipid-metabolism-driven ferroptosis

  Relevance score: 0.00

  Yang-Che Wu, Chin-Sheng Huang, Ming-Shou Hsieh, Chih-Ming Huang, Syahru Agung Setiawan, Chi-Tai Yeh, Kuang-Tai Kuo, Shao-Cheng Liu

  Keywords: drug-tolerant persister cancer cells, tumor organoids, ferroptosis, FSP1

  Published in Aging on January 10, 2024

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• Research PaperVolume 15, Issue 21pp 12251-12263

  Polyphyllin I attenuates the invasion and metastasis via downregulating GRP78 in drug-resistant hepatocellular carcinoma cells

  Relevance score: 0.00

  Haiyan Du, Haochen Wu, Qinyang Kang, Mianmian Liao, Meirong Qin, Ning Chen, Houshuang Huang, Danping Huang, Ping Wang, Guangdong Tong

  Keywords: Polyphyllin I, invasion and metastasis, sorafenib-resistant, GRP78, hepatocellular carcinoma

  Published in Aging on November 6, 2023

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• Research PaperVolume 14, Issue 17pp 7038-7051

  The downregulated drug-metabolism related ALDH6A1 serves as predictor for prognosis and therapeutic immune response in gastric cancer

  Relevance score: 0.00

  Yuan Cai, Rong Zeng, Jinwu Peng, Wei Liu, Qingchun He, Zhijie Xu, Ning Bai

  Keywords: ALDH6A1, gastric cancer, drug-metabolism, prognosis, immune regulation

  Published in Aging on September 12, 2022

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• Research PaperVolume 12, Issue 22pp 22700-22718

  Drug-selected population in melanoma A2058 cells as melanoma stem-like cells retained angiogenic features – the potential roles of heparan-sulfate binding ANGPTL4 protein

  Relevance score: 0.00

  Chia-Yu Shih, Yu-Che Cheng, ChiaoHui Hsieh, TingTing Tseng, ShihSheng Jiang, Shao-Chen Lee

  Keywords: drug resistance, melanoma stem-like cells, angiopoietin-like 4 protein

  Published in Aging on November 10, 2020

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• Research PaperVolume 12, Issue 19pp 19711-19739

  Risk of hospitalization from drug-drug interactions in the Elderly: real-world evidence in a large administrative database

  Relevance score: 0.00

  Floor Swart, Giampaolo Bianchi, Jacopo Lenzi, Marica Iommi, Lorenzo Maestri, Emanuel Raschi, Marco Zoli, Fabrizio De Ponti, Elisabetta Poluzzi

  Keywords: drug-drug interactions, adverse drug reactions, elderly, case-control study, real-world evidence

  Published in Aging on October 5, 2020

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• Research PaperVolume 13, Issue 12pp 16316-16340

  Comprehensive signature analysis of drug metabolism differences in the White, Black and Asian prostate cancer patients

  Relevance score: 0.00

  Yang Liu, Jia-Wei Zhou, Cun-Dong Liu, Jian-Kun Yang, De-Ying Liao, Zhi-Jian Liang, Xiao Xie, Qi-Zhao Zhou, Kang-Yi Xue, Wen-Bing Guo, Ming Xia, Jun-Hao Zhou, Ji-Ming Bao, Cheng Yang, Hai-Feng Duan, Hong-Yi Wang, Zhi-Peng Huang, Shan-Chao Zhao, Ming-Kun Chen

  Keywords: prostate cancer, race, drug resistance, drug metabolism, comprehensive signature

  Published in Aging on June 18, 2021

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